Progress in hepatitis B: a 30-year journey through three continents.
Progress in hepatitis B: a 30-year journey through three continents.
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DOI：
10.1002/hep.27120
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发表时间：
2014-07
期刊：
影响因子：
13.5
通讯作者：
Lok, Anna Suk-Fong
中科院分区：
文献类型：
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作者：
Lok, Anna Suk-Fong
被邀请在《肝脏病学》杂志上发表一篇《大师视角》的文章是一种莫大的荣誉，我战战兢兢地接受了这一邀请。在准备本文的过程中，我回顾了前面的几篇文章，并意识到每一篇文章都讲述了不同的故事。我希望这篇文章能说明在过去的30年里，我们对乙肝的理解取得了多大的进步。我也希望，我的个人旅程将激励年轻读者相信他们的梦想，即使道路曲折，充满障碍，也要朝着他们的目标努力。我在香港一个从未有过内科医生的家庭长大。事实上，我是我们家第一个在高中时选择科学轨道的人(我们在8年级末被迫在科学轨道和人文轨道之间做出选择)。我父亲告诫说，科学不适合女孩。当我的第一次物理考试得了“C”的时候，我想我应该听那位老人的。幸运的是，历史没有重演。在我的O级考试(所有学校的孩子都会在11年级末参加的考试)结束后，我申请了一所理科有名气的男校(从一所语言和人文学科都很强的女校搬来)，并被全班31名男孩中唯一的女孩录取。作为一个奇怪的人，男孩们超级友好和有礼貌，老师们非常同情我，最终我连续两年名列班级第一。当我宣布我将在13年级末申请医学院时(上大学是一种不必要的时间浪费)，我父亲建议说，护士更适合女孩，但当我被医学院录取时，他很高兴。医学院的5年时间过得很快。实习一年后，我得到了香港大学医学系的一个讲师职位。当时几乎没有教员，像我这样的住院医生被征召来教医学生(除了所有的临床职责之外，没有工作时间限制)。薪水与其他住院医生一样，没有教学职责，但额外的好处是大学赞助海外奖学金培训。在我作为住院医生的第一次轮换中，我爱上了肝病。有两个人对我成为肝病专家的决定产生了很大影响。KC Lam1博士是我的主治医生，Rudi Schmidd博士(加州大学旧金山分校胃肠病和肝病学主任)是客座教授。两人都是鼓舞人心的老师，他们在查房时问了很多问题，让我思考并想知道更多。我们的生活是如何被命运或偶然相遇塑造的，这是令人惊讶的。正如我前面提到的，作为一名住院医生，承担额外教学职责的额外好处是赞助海外奖学金培训。免费赠送让我更容易进入最好的课程。由希拉·夏洛克爵士领导的伦敦皇家自由医院是当时肝病的圣地。我在皇家自由酒店的两年是我一生中最美好的时光。在皇家自由学院的培训和经历为我的学术生涯奠定了坚实的基础。同样重要的是，我成为了夏洛克肝病大家庭的一员(图1)，而夏洛克的品牌是我在美国获得教职的一个主要原因，尽管我从未在这个国家接受过任何培训。肝病在20世纪80年代初是一个相当新的专业(《肝病》杂志于1981年1月创刊)。从香港传来的，是
Being asked to contribute a Master Perspective article in HEPATOLOGY is a great honor that I accepted with trepidation. In preparation for this article, I reviewed the previous ones and realized each tells a different story. I hope this article will illustrate how much progress we have made in our understanding of hepatitis B in the last 30 years. I also hope that my personal journey will inspire young readers to believe in their dreams and to strive towards their goals even when the path is tortuous and riddled with hurdles. I grew up in Hong Kong in a family where there had never been a physician. In fact, I was the first in my family to choose a science track in high school (we were forced to choose between science and humanity tracks at the end of 8th grade). My father cautioned that science is not for girls. When I got a “C” for my first physics test, I thought I should have listened to the old man. Fortunately, history did not repeat itself. After my “O Level” exam (an exam that kids from all schools take at the end of 11th grade), I applied to a boys’ school with a reputation in science (a move from an all-girls’ school strong in language and humanities) and was accepted as the only girl in a class of 31 boys.Being the odd person out, the boys were super nice and polite, and the teachers were so sympathetic that I ended up ranking top of the class 2 years in a row. When I announced that I would be applying for medical school at the end of 13th grade (college was an unnecessary waste of time), my father advised that nursing would be more appropriate for girls but he was delighted when I was accepted into medical school. The 5 years of medical school flew by quickly. After a year of internship, I was offered a lecturer position in the Department of Medicine, University of Hong Kong. There were very few faculty then and residents like myself were drafted to teach medical students (on top of all the clinical duties, there were no work-hour limits). Salaries were the same as other residents with no teaching duties but the perk was university sponsorship of overseas fellowship training. I fell in love with hepatology during my first rotation as a resident. Two people had a big influence on my decision to be a hepatologist. Dr. KC Lam1 was my attending and Dr. Rudi Schmid (Chief of Gastroenterology and Hepatology at University of California-San Francisco) was a visiting professor. Both were inspiring teachers who asked a lot of questions on rounds and made me think and want to know more. It is amazing how our lives are shaped by fate or chance encounter. As I mentioned earlier, the perk of taking on additional teaching duties as a resident was sponsorship of overseas fellowship training. Being a freebie made it easier for me to get into the best program. The Royal Free Hospital in London, headed by Dame Sheila Sherlock, was the mecca of hepatology at that time. My 2 years at the Royal Free were some of the best times in my life. The training and experience at the Royal Free provided solid foundations for my academic career. Just as important, if not more, I became a member of the Sherlock Hepatology Family (Fig. 1) and the Sherlock brand name was a major reason how I landed with a faculty position in the United States despite never having any training in the country. Hepatology was a fairly new specialty in the early 1980s (the Journal HEPATOLOGY was inaugurated in January 1981). Coming from Hong Kong, it was
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影响因子：
13.5
作者：
Kowdley, Kris V.;Wang, Chia C.;Brosgart, Carol L.
通讯作者：
Brosgart, Carol L.
影响因子：
158.5
作者：
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通讯作者：
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影响因子：
13.5
作者：
HOOFNAGLE, JH;MINUK, GY;ISHAK, K
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影响因子：
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作者：
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通讯作者：
THOMAS, HC
影响因子：
13.5
作者：
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通讯作者：
THOMAS, HC