Decoding chemical communication in nematodes.

Decoding chemical communication in nematodes.
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DOI:
10.1039/c7np00007c
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发表时间:
2017-05-10
影响因子:
11.9
通讯作者:
Butcher RA
Butcher RA
中科院分区:
化学1区
文献类型:
--
作者:
Butcher RA

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秀丽隐杆线虫产生数十种(如果不是数百种)不同的蛔虫苷作为信息素,与其物种的其他成员进行交流。这些信息素的重叠混合物会影响蠕虫的发育和各种不同的行为。蛔虫苷代表了一种独特的工具,用于解剖控制行为的神经回路,并连接到重要的信号传导通路,如胰岛素和TGFβ通路,这些通路位于C中发育,代谢和寿命的关系中。优雅然而,许多蛔虫苷的确切生理作用尚不清楚,特别是因为这些信息素中的许多可能具有多种功能,这取决于它们的浓度、其他信息素的存在以及各种其他因素。确定这些生理作用将促进自上而下的方法来表征信息素受体及其功能,以及自下而上的方法来表征信息素生物合成酶及其调节。
The nematode Caenorhabditis elegans produces tens, if not hundreds, of different ascarosides as pheromones to communicate with other members of its species. Overlapping mixtures of these pheromones affect the development of the worm and a variety of different behaviors. The ascarosides represent a unique tool for dissecting the neural circuitry that controls behavior and that connects to important signaling pathways, such as the insulin and TGFβ pathways, that lie at the nexus of development, metabolism, and lifespan in C. elegans. However, the exact physiological roles of many of the ascarosides are unclear, especially since many of these pheromones likely have multiple functions depending on their concentrations, the presence of other pheromones, and a variety of other factors. Determining these physiological roles will be facilitated by top-down approaches to characterize the pheromone receptors and their function, as well as bottom-up approaches to characterize the pheromone biosynthetic enzymes and their regulation.
比较代谢组学揭示了丙烷剂的生物发生,这是秀丽隐杆线虫中小分子信号的模块化库。
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