Significance of platelet count in esophageal carcinomas.
Significance of platelet count in esophageal carcinomas.
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DOI：
10.4103/1319-3767.77245
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Mirsharifi A
中科院分区：
文献类型：
--
作者：
Aminian A;Karimian F;Mirsharifi R;Alibakhshi A;Dashti H;Jahangiri Y;Safari S;Ghaderi H;Noaparast M;Hasani SM;Mirsharifi A
血小板增多与食管癌预后不良有关。血小板产生胸苷磷酸化酶，这是一种血小板衍生的内皮细胞生长因子，具有血管生成活性。血小板计数的增加可能会转化为肿瘤生长的增强。我们研究了食管癌患者血小板计数与几个预后变量之间的关系。本文回顾性分析了某肿瘤研究所近五年来收治的381例食管癌患者的临床资料。分析术前血小板计数与患者年龄、性别、肿瘤部位、是否存在多发癌以及临床病理特征（包括组织学类型、肿瘤大小、浸润深度（T）、淋巴结受累（N）、远处转移（M）、分化程度、是否存在血管、淋巴和神经周围浸润）的关系。鳞状细胞癌（SCC）占93%，腺癌占7%。大多数患者处于III期，其次是II期。平均血小板计数为245±76（× 109 /L）。血小板计数与预后因素之间无统计学显著相关性，但血小板计数与肿瘤大小之间存在弱线性相关性（P= 0.03，Pearson相关系数：0.16）。腺癌患者的血小板计数高于SCC患者（P= 0.003）。血小板计数与食管癌预后因素无关。而食管鳞癌与食管腺癌之间有显著性差异。
Thrombocytosis is found to be associated with unfavorable prognosis in esophageal carcinoma. Platelets produce thymidine phosphorylase which is a platelet-derived endothelial cell growth factor with angiogenic activity. Increased platelet count may be translated into enhanced tumor growth. We examined the relation between platelet count and several prognostic variables in patients with esophageal cancer. Three hundred and eighty-one cases with esophageal cancer that underwent esophagectomy in a referral cancer institute during a 5-year period were studied retrospectively. The relation between preoperative platelet count and patient age, gender, site of tumor, presence of multiple cancers and clinicopathological characteristics including histological type, tumor size, depth of penetration (T), lymph node involvement (N), distant metastasis (M), degree of differentiation, presence of vascular, lymphatic and perineural invasion was examined. Squamous cell carcinoma (SCC) constituted 93% and adenocarcinoma 7% of cases. Most of patients were in stage III, followed by stage II. The mean platelet count was 245±76 (× 109 /L). There was no statistically significant correlation between platelet counts with prognostic factors except a weak linear correlation between platelet count and and tumor size (P= 0.03, Pearson correlation coefficient: 0.16). Patients with adenocarcinoma had a higher platelet count than those with SCC (P= 0.003). Platelet count does not correlate with prognostic factors in esophageal cancer. However, it is significantly different between SCC and adenocarcinoma of esophagus.
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影响因子：
1.6
作者：
Ikeguchi, M;Oka, S;Kaibara, N
通讯作者：
Kaibara, N
影响因子：
2.3
作者：
Alibakhshi, Abbas;Aminian, Ali;Karimian, Faramarz
通讯作者：
Karimian, Faramarz
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
6.2
作者：
Shimada, H;Takeda, A;Ochiai, T
通讯作者：
Ochiai, T
DOI：
10.1016/j.jamcollsurg.2004.01.022
发表时间：
2004-05-01
影响因子：
5.2
作者：
Shimada, H;Oohira, G;Ochiai, T
通讯作者：
Ochiai, T