Ocular inflammation in Behçet disease: incidence of ocular complications and of loss of visual acuity.
Ocular inflammation in Behçet disease: incidence of ocular complications and of loss of visual acuity.
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DOI：
10.1016/j.ajo.2008.06.019
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发表时间：
2008-12
影响因子：
4.2
通讯作者：
Foster, C. Stephen
中科院分区：
文献类型：
--
作者：
Kacmaz, R. Oktay;Kempen, John H.;Newcomb, Craig;Gangaputra, Sapna;Daniel, Ebenezer;Levy-Clarke, Grace A.;Nussenblatt, Robert B.;Rosenbaum, James T.;Suhler, Eric B.;Thorne, Jennifer E.;Jabs, Douglas A.;Foster, C. Stephen
目的评估behaperet病（BD）患者发生结构性眼部并发症和视力丧失的风险；回顾性队列研究5个学术中心眼部炎症亚专科实践共168例bd相关性眼部炎症患者的临床资料通过标准化的图表回顾确定这些患者的视力、眼部炎症的结构性并发症、眼压（IOP）中位随访时间为1.05年。特殊结构并发症和IOP紊乱发生率普遍：眼部并发症发生率为0.45/眼年（EY）。视力下降至20/50及以下和20/200及以下的比率分别为0.12/EY和0.09/EY。随访期间视力丧失的危险因素是持续的炎症活动、后粘连的存在、低眼压的存在和IOP升高。在一项时间依赖性分析中，当前眼部炎症的活动性与视力下降的风险增加相关，视力下降至20/50或更差（RR = 2.45, 95% CI: 1.1-5.5, p = 0.03）和视力下降至20/200或更差（RR = 2.67, 95% CI: 1.2-5.8, p = 0.01）。视力丧失和眼部并发症的发生在与behaperet病相关的眼部炎症患者中很常见，即使经过积极的治疗。随访期间持续的炎症、后粘连的存在/发生、低斜视和IOP升高与视力丧失的风险增加相关。
To estimate the risk of structural ocular complications and loss of visual acuity in cases of Behçet’s Disease (BD); to evaluate potential risk and protective factors for these events Retrospective cohort study Five academic center ocular inflammation subspecialty practices A total of 168 consecutive patients with BD-associated ocular inflammation Clinical data on these patients were ascertained by standardized chart review Visual acuity, structural ocular complications of inflammation, intraocular pressure (IOP) Over a median follow-up of 1.05 years, the incidence of specific structural complications and IOP disturbances were common: the incidence rate of any ocular complication was 0.45/eye-year (EY). Rates of loss of visual acuity to 20/50 or worse and to 20/200 or worse were 0.12/EY and 0.09/EY respectively. Risk factors for loss of visual acuity during follow-up were persistent inflammatory activity, presence of posterior synechiae, presence of hypotony, and presence of elevated IOP. In a time-dependent analysis, current activity of ocular inflammation was associated with an increased risk of loss of visual acuity to 20/50 or worse (RR = 2.45, 95% CI: 1.1–5.5, p = 0.03) and to 20/200 or worse (RR = 2.67, 95% CI: 1.2–5.8, p = 0.01). Loss of visual acuity and occurrence of ocular complications were common in patients with ocular inflammation associated with Behçet’s Disease, even with aggressive therapy. Ongoing inflammation during follow-up, presence/occurrence of posterior synechiae, hypotony, and elevated IOP were associated with an increased risk of loss of visual acuity.
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影响因子：
1.8
作者：
Kempen, John H.;Daniel, Ebenezer;Suhler, Eric B.
通讯作者：
Suhler, Eric B.
影响因子：
3.4
作者：
Krause, Ilan;Yankevich, Anna;Weinberger, Abraham
通讯作者：
Weinberger, Abraham
影响因子：
3.3
作者：
Muhaya, M;Lightman, S;Towler, HMA
通讯作者：
Towler, HMA
影响因子：
4.2
作者：
Tugal-Tutkun, I;Onal, S;Urgancioglu, M
通讯作者：
Urgancioglu, M
影响因子：
2.4
作者：
Accorinti, Massimo;Pirraglia, Maria Pia;Pivetti-Pezzi, Paola
通讯作者：
Pivetti-Pezzi, Paola