Moderate adolescent chronic intermittent ethanol exposure sex-dependently disrupts synaptic transmission and kappa opioid receptor function in the basolateral amygdala of adult rats.
Moderate adolescent chronic intermittent ethanol exposure sex-dependently disrupts synaptic transmission and kappa opioid receptor function in the basolateral amygdala of adult rats.
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DOI：
10.1016/j.neuropharm.2021.108512
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发表时间：
2021-05-01
影响因子：
4.7
通讯作者：
Diaz, Marvin R.
中科院分区：
文献类型：
--
作者：
Przybysz, Kathryn R.;Gamble, Meredith E.;Diaz, Marvin R.
关键词：
青少年酒精暴露与成年后的许多后果有关，包括改变情感和与奖励相关的行为。然而，这些行为背后的长期神经紊乱还没有完全被理解。杏仁基底外侧核(BLA)兴奋/抑制平衡的改变与这些行为的表达有关，在青少年酒精暴露后立即戒断的过程中，BLA生理发生了变化，但没有研究检验这些变化是否会长期存在。Kappa阿片受体(KOR)神经调节系统介导负性情绪行为，该系统的改变与成人和青少年慢性酒精暴露后的行为改变有关。在BLA中，KOR系统在发育过程中经历了功能变化，但BLA KOR功能是否受到青少年酒精暴露的干扰尚不清楚。在这项研究中，雄性和雌性SD大鼠暴露在中度青少年慢性间歇性乙醇(ACIE)的蒸气模型中，并评估了这些系统对成年BLA和KOR系统内GABA和谷氨酸能神经传递的长期影响。Acie暴露增加了女性突触前谷氨酸的传递，但对男性或两性的GABA传递没有影响。此外，Acie暴露扰乱了雄性KOR对GABA释放的调节，对雌性没有影响，也没有影响谷氨酸的传递。这些数据表明，Acie会对BLA生理和KOR功能产生性别依赖性和长期的变化。这是第一次研究青少年酒精暴露后的这些持续性适应，并为未来研究其他青少年酒精引起的这些系统中断开辟了一条广阔的道路。
Adolescent alcohol exposure is associated with many consequences in adulthood, including altered affective and reward-related behaviors. However, the long-term neurological disruptions underlying these behaviors are not fully understood. Shifts in the excitatory/inhibitory balance in the basolateral amygdala (BLA) relate to the expression of these behaviors and changes to BLA physiology are seen during withdrawal immediately following adolescent ethanol exposure, but no studies have examined whether these changes persist long-term. The kappa opioid receptor (KOR) neuromodulatory system mediates negative affective behaviors, and alterations of this system are implicated in behavioral changes following adult and adolescent chronic ethanol exposure. In the BLA, the KOR system undergoes functional changes across development, but whether BLA KOR function is disrupted by adolescent ethanol exposure is unknown. In this study, male and female Sprague-Dawley rats were exposed to a vapor model of moderate adolescent chronic intermittent ethanol (aCIE) and assessed for long-term effects on GABAergic and glutamatergic neurotransmission within the adult BLA and KOR modulation of these systems. aCIE exposure increased presynaptic glutamate transmission in females but had no effect in males or on GABA transmission in either sex. Additionally, aCIE exposure disrupted male KOR modulation of GABA release, with no effects in females or on glutamate transmission. These data suggest that aCIE produces sex-dependent and long-term changes to BLA physiology and KOR function. This is the first study to examine these persistent adaptations following adolescent alcohol exposure and opens a broad avenue for future investigation into other adolescent ethanol-induced disruptions of these systems.
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影响因子：
2.9
作者：
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通讯作者：
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