Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
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DOI：
10.1016/j.chom.2009.04.012
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发表时间：
2009-05-08
影响因子：
30.3
通讯作者：
Kalman D
中科院分区：
文献类型：
--
作者：
Anyanful A;Easley KA;Benian GM;Kalman D
秀丽隐杆线虫表现出回避行为时，提出了不同的细菌病原体。我们假设，暴露于病原体可能不仅会导致蠕虫离开，但也同时激活途径，促进抵抗病原体。我们表明，短暂暴露于致病性大肠杆菌的强毒株或无毒毒株。大肠杆菌（EPEC）“条件”或“免疫”C.在随后的暴露中存活下来，否则会被证明是致命的。条件反射需要多巴胺能神经元。条件反射还需要调节先天免疫的p38 MAP激酶途径和调节寿命的胰岛素/IGFR途径。我们的研究结果表明，调节先天免疫和寿命并提供保护的分子途径在本质上可能通过暴露于病原体来调节或“调节”，并且可能允许在有害环境中生存。
Caenorhabditis elegans exhibit avoidance behavior when presented with diverse bacterial pathogens. We hypothesized that exposure to pathogens might not only cause worms to move away but also simultaneously activate pathways that promote resistance to the pathogen. We show that brief exposure to the virulent or avirulent strains of the bacterial pathogen enteropathogenic E. coli (EPEC) “conditions” or “immunizes” C. elegans to survive a subsequent exposure that would otherwise prove lethal. Conditioning requires dopaminergic neurons. Conditioning also requires the p38 MAP Kinase pathway, which regulates innate immunity, and the insulin/IGFR pathway, which regulates lifespan. Our findings suggest that the molecular pathways that regulate innate immunity and lifespan and provide protection may, in nature, be regulated or “conditioned” by exposure to pathogens, and perhaps allow survival in noxious environments.
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影响因子：
10.5
作者：
Hamilton, B;Doug, YQ;Lee, SS
通讯作者：
Lee, SS
影响因子：
56.9
作者：
Garsin, DA;Villanueva, JM;Ausubel, FM
通讯作者：
Ausubel, FM
影响因子：
56.9
作者：
Kim, DH;Feinbaum, R;Ausubel, FM
通讯作者：
Ausubel, FM
DOI：
10.1073/pnas.96.26.15202
发表时间：
1999-12-21
影响因子：
11.1
作者：
Darby, C;Cosma, CL;Manoil, C
通讯作者：
Manoil, C
影响因子：
6.4
作者：
LEVINE, MM;NATARO, JP;OBRIEN, AD
通讯作者：
OBRIEN, AD