Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro
Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro
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静电纺丝 SF/P(LLA-CL) 混合纳米纤维支架的体外降解
DOI：
10.1016/j.polymdegradstab.2011.08.011
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发表时间：
2011-12
影响因子：
5.9
通讯作者：
El-Newehy, Mohamed
中科院分区：
文献类型：
--
作者：
Zhang, Kuihua;Yin, Anlin;Huang, Chen;Wang, Chunyang;Mo, Xiumei;Al-Deyab, Salem S.;El-Newehy, Mohamed
Nanofibrous scaffolds of silk fibroin (SF) and poly(l-lactic acid-co-ɛ-caprolactone) (P(LLA-CL)) blends fabricated via electrospinning possessed good mechanical property and biocompatibility, as demonstrated by a previous study in vitro. However, the degradation behavior of the scaffolds, which may significantly influence tissue repair and regeneration, needs further exploration. In this study, in vitro degradation of pure SF, P(LLA-CL) and SF/P(LLA-CL) blended nanofibrous scaffolds were performed in phosphate-buffered saline (PBS, pH 7.4 ± 0.1) at 37 °C for 6 months. A series of analyses and characterizations (including morphologic changes, loss weight, pH changes of PBS solutions, DSC, XRD and FTIR-ATR) were conducted to the nanofibrous scaffolds after degradation and the results showed that the pure SF nanofibrous scaffolds were not completely degradable in PBS while pure P(LLA-CL) nanofibrous scaffolds had the fastest degradation rate. Moreover, the addition of SF reduced the degradation rate of P(LLA-CL) in SF/P(LLA-CL) blended nanofibrous scaffolds. This was probably caused by the intermolecular interactions between SF and P(LLA-CL), which hindered the movement of P(LLA-CL) molecular chains.
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影响因子：
6.2
作者：
Vasconcelos, Andreia;Freddi, Giuliano;Cavaco-Paulo, Artur
通讯作者：
Cavaco-Paulo, Artur
影响因子：
14
作者：
Hong, Yi;Ye, Sang-Ho;Nieponice, Alejandro;Soletti, Lorenzo;Vorp, David A.;Wagner, William R.
通讯作者：
Wagner, William R.
影响因子：
4.3
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Yijiang Liu;Hongliang Jiang;Y. Li;K. Zhu
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影响因子：
3.8
作者：
Chen, X;Shao, ZZ;Chance, MR
通讯作者：
Chance, MR
影响因子：
5.9
作者：
Y. You;S. Lee;J. Youk;B. Min;S. -. Lee;W. Park
通讯作者：
Y. You;S. Lee;J. Youk;B. Min;S. -. Lee;W. Park