Impact of Maternal Glucose and Gestational Weight Gain on Child Obesity over the First Decade of Life in Normal Birth Weight Infants.
Impact of Maternal Glucose and Gestational Weight Gain on Child Obesity over the First Decade of Life in Normal Birth Weight Infants.
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DOI：
10.1007/s10995-016-1955-7
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发表时间：
2016-08
影响因子：
2.3
通讯作者：
Ogasawara, Keith K.
中科院分区：
文献类型：
--
作者：
Hillier, Teresa A.;Pedula, Kathryn L.;Vesco, Kimberly K.;Oshiro, Caryn E. S.;Ogasawara, Keith K.
关键词：
为了确定，在出生体重正常的儿童中，母亲高血糖和体重增加是否在一个非常大的不同人群中独立增加了儿童肥胖的风险。研究人群为24,141人（母亲及其出生体重正常的后代，1995-2003年出生），在不同人群中进行通用GDM筛查（50克葡萄糖刺激试验[GCT]； 3小时）。GCT+ 100g口服葡萄糖耐量试验[OGTT]。在13037例出生体重正常（2500-4000g）的足月子代中，采用美国标准（1964-1990年标准）确定了2-10岁之间的年测量身高/体重，以计算性别不同的bmi年龄百分位数。在出生体重正常的儿童中，我们发现，在出生后的头十年中，伴有母亲高血糖（GCT正常，GCT+，但没有GDM， GDM）和妊娠体重过度增加（>40磅[18.1千克]）的儿童超重（>85%）和肥胖（>95%）的显著趋势；两种趋势的P <0.0001。在调整了潜在的混杂因素（包括母亲年龄、胎次和孕前BMI）后，这些母亲葡萄糖和/或体重增加对儿童肥胖的影响在前十年仍然存在。GDM的儿童肥胖归因风险（%）为28.5% (95% CI: 15.9-41.1)，妊娠期体重增加过多的儿童肥胖归因风险（%）为16.4% （95% CI: 9.4-23.2）。母亲高血糖和体重过度增加对儿童肥胖风险的增加都有独立的影响。未来的研究应该把重点放在怀孕期间的预防工作上，作为减少儿童肥胖的潜在机会。
To determine, among children with normal birth weight, if maternal hyperglycemia and weight gain independently increase childhood obesity risk in a very large diverse population. Study population was 24,141 individuals (mothers and their normal birth weight offspring, born 1995-2003) among a diverse population with universal GDM screening (50-gram glucose-challenge test [GCT]; 3 hr. 100g oral glucose tolerance test [OGTT] if GCT+). Among the 13,037 full-term offspring with normal birth weight (2500-4000g), annual measured height/weight was ascertained between ages 2-10 years to calculate gender-specific BMI-for-age percentiles using USA norms (1964-1990 standard). Among children who began life with normal birth weight, we found a significant trend for developing both childhood overweight (>85%ile) and obesity (>95%ile) during the first decade of life with both maternal hyperglycemia (normal GCT, GCT+ but no GDM, GDM) and excessive gestational weight gain (>40 pounds [18.1kg]); p<0.0001 for both trends. These maternal glucose and/or weight gain effects to imprint for childhood obesity in the first decade remained after adjustment for potential confounders including maternal age, parity, as well as pre-pregnancy BMI. The attributable risk (%) for childhood obesity was 28.5% (95% CI: 15.9-41.1) for GDM and 16.4% (95% CI: 9.4-23.2) for excessive gestational weight gain. Both maternal hyperglycemia and excessive weight gain have independent effects to increase childhood obesity risk. Future research should focus on prevention efforts during pregnancy as a potential window of opportunity to reduce childhood obesity.
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影响因子：
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作者：
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DOI：
10.1016/j.beem.2012.03.002
发表时间：
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影响因子：
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作者：
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