Obesity and the microvasculature: a systematic review and meta-analysis.
Obesity and the microvasculature: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0052708
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
META-EYE Study Group
中科院分区：
文献类型：
--
作者：
Boillot A;Zoungas S;Mitchell P;Klein R;Klein B;Ikram MK;Klaver C;Wang JJ;Gopinath B;Tai ES;Neubauer AS;Hercberg S;Brazionis L;Saw SM;Wong TY;Czernichow S;META-EYE Study Group
超重和肥胖被认为会显着影响一个人患心血管疾病的风险，这可能是通过其对微脉管系统的影响而实现的。视网膜血管口径是微血管疾病的替代标志物和心血管事件的预测因子。本系统评价和荟萃分析的目的是确定体重指数 (BMI) 与视网膜血管口径之间的关联。通过检索 1966 年至 2011 年 8 月的 MEDLINE 和 EMBASE 数据库确定了相关研究。使用标准化表格进行数据提取。在超过 44,000 名个体中，与正常体重受试者相比，肥胖受试者的小动脉口径更窄，静脉口径更宽，与传统的心血管危险因素无关。在成人中，体重指数每增加 1 kg/m2，就会产生 0.07 μm 的差异[95% CI：-0.08； -0.06] 小动脉口径和 0.22 μm [95% CI: 0.21; 0.23]小静脉口径。对于儿童也有类似的结果。较高的体重指数与较窄的视网膜小动脉和较宽的小静脉口径相关。需要进一步的前瞻性研究来检验体重指数和视网膜微循环之间是否存在因果关系。
Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber. Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m2 increase in BMI was associated with a difference of 0.07 μm [95% CI: −0.08; −0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children. Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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作者：
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