Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: duration of use and gender difference.
Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: duration of use and gender difference.
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DOI：
10.1016/j.drugalcdep.2013.09.004
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发表时间：
2014-01-01
影响因子：
4.2
通讯作者：
Li, Chiang-shan R.
中科院分区：
文献类型：
--
作者：
Ide, Jaime S.;Zhang, Sheng;Hu, Sien;Sinha, Rajita;Mazure, Carolyn M.;Li, Chiang-shan R.
核磁共振成像提供了大量关于可卡因成瘾者大脑活动和结构改变的信息。然而，很少有研究考虑到年龄和酒精使用对这些变化的影响。我们用基于体素的形态测量（VBM）和BOLD信号的低频波动（LFF）来检测84名可卡因依赖（CD）和86名健康对照（HC）受试者的脑活动。我们进行了协方差分析，以解释年龄和饮酒年限的影响。与HC相比，CD个体在额叶和颞叶皮层、中/后扣带皮层和小脑的灰质（GM）体积减少，p<0.05，经多次比较校正。双侧额上回（SFG）和扣带皮层的GM体积与可卡因使用年限呈负相关，女性右侧额上回体积的急剧下降与使用时间有关。相比之下，与HC个体相比，CD患者右侧腹侧壳核的GM体积增加。与HC相比，CD个体表现出丘脑LFF分数振幅（fALFF）的增加，与显示GM体积损失的区域没有明显重叠。这些结果表明，慢性可卡因使用与大脑结构和活动的明显变化有关，这些变化可以通过BOLD信号的GM体积和fALFF来捕捉。
Magnetic resonance imaging has provided a wealth of information on altered brain activations and structures in individuals addicted to cocaine. However, few studies have considered the influence of age and alcohol use on these changes. We examined gray matter volume with voxel based morphometry (VBM) and low frequency fluctuation (LFF) of BOLD signals as a measure of cerebral activity of 84 cocaine dependent (CD) and 86 healthy control (HC) subjects. We performed a covariance analysis to account for the effects of age and years of alcohol use. Compared to HC, CD individuals showed decreased gray matter (GM) volumes in frontal and temporal cortices, middle/posterior cingulate cortex, and the cerebellum, at p<0.05, corrected for multiple comparisons. The GM volume of the bilateral superior frontal gyri (SFG) and cingulate cortices were negatively correlated with years of cocaine use, with women showing a steeper loss in the right SFG in association with duration of use. In contrast, the right ventral putamen showed increased GM volume in CD as compared to HC individuals. Compared to HC, CD individuals showed increased fractional amplitude of LFF (fALFF) in the thalamus, with no significant overlap with regions showing GM volume loss. These results suggested that chronic cocaine use is associated with distinct changes in cerebral structure and activity that can be captured by GM volume and fALFF of BOLD signals.
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