Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France.
Hesitancy towards COVID-19 Vaccination among Healthcare Workers: A Multi-Centric Survey in France.
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DOI：
10.3390/vaccines9060547
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发表时间：
2021-05-22
期刊：
影响因子：
7.8
通讯作者：
On Behalf Of The Acv Alpin Study Group
中科院分区：
文献类型：
--
作者：
Janssen C;Maillard A;Bodelet C;Claudel AL;Gaillat J;Delory T;On Behalf Of The Acv Alpin Study Group
针对新冠肺炎的疫苗接种计划正在扩大。我们的目标是在2020年12月1日至2021年3月26日在法国医疗机构内进行的一项多中心调查中，评估疫苗特性对医务人员疫苗犹豫不决的影响。我们邀请任何对接种新冠肺炎疫苗天真的医护人员完成在线自我问卷调查。他们报告了他们的社会人口特征，以及他们对疫苗接种的看法和信念。我们测量了他们在8种情况下接种疫苗的意愿，这些情景是按顺序提供的候选人疫苗(1到4分制)。候选疫苗的疗效(25%、50%、100%)、免疫持续时间(1年或终生)、频率(1/100、1/10,000)和不良事件的严重程度(无、中度、重度)各不相同。采用可解释性问卷对4349名医护人员的回答进行了分析。接种疫苗的粗略意愿为53.2%，并随着时间的推移而增加。我们使用非监督分类算法(k-Means)对反应的轨迹进行了聚类，并确定了四组医护人员：在任何情况下都愿意接种疫苗的人(18%)，根本不愿意接种的人(22%)，以及那些犹豫不决但更有可能接受或拒绝接种的人(32%)或(28%)，具体取决于情况。在后两个亚组中，疫苗接受率随着年龄和教育背景的增加而增加，在有条件的男性中更高。与理想的候选疫苗相比，50%的减效率导致接受度平均下降0.8%(SD±0.8，−23.5%)，而对于严重但罕见的不良事件，其接受度在1.4(SD±1.0，−38.4%)至2.1(SD±1.0，−58.4%)之间。对强制免疫方案的接受率为29.6%，与接种意愿呈正相关，在2.4%~60.0%之间。即使医护人员代表着一个不同种族的人群，大多数(80%)也可以接受针对新冠肺炎的疫苗接种。他们接种疫苗的意愿随着时间的推移和免疫计划的推出而增加。在犹豫不决的专业人士中，对不良事件的恐惧是主要的担忧。在一个对强制免疫计划有强烈意见的人群中，有针对性的信息运动让人们对不良事件放心，可能会增加疫苗覆盖率。
Vaccination programs against COVID-19 are being scaled up. We aimed to assess the effects of vaccine characteristics on vaccine hesitancy among healthcare workers in a multi-center survey conducted within French healthcare facilities from 1 December 2020 to 26 March 2021. We invited any healthcare workers naïve of COVID-19 vaccination to complete an online self-questionnaire. They reported on their socio-demographic characteristics, as well as their perception and beliefs towards vaccination. We measured their willingness to get vaccinated in eight scenarios for candidates’ vaccines presented sequentially (1 to 4-point scale). Candidates’ vaccines varied for efficacy (25%, 50%, 100%), length of immunization (1 year or lifetime), frequency (<1/100, <1/10,000), and severity (none, moderate, severe) of adverse events. We analyzed 4349 healthcare workers’ responses with interpretable questionnaires. The crude willingness to get vaccinated was 53.2% and increased over time. We clustered the trajectories of responses using an unsupervised classification algorithm (k-means) and identified four groups of healthcare workers: those willing to get vaccinated in any scenario (18%), those not willing to get vaccinated at all (22%), and those hesitating but more likely to accept (32%) or reject (28%) the vaccination depending on the scenario. In these last two subgroups, vaccine acceptance was growing with age, educational background and was higher among men with condition. Compared to an ideal vaccine candidate, a 50% reduced efficacy resulted in an average drop in acceptance by 0.8 (SD ± 0.8, −23.5%), while it was ranging from 1.4 (SD ± 1.0, −38.4%) to 2.1 (SD ± 1.0, −58.4%) in case of severe but rare adverse event. The acceptance of a mandatory immunization program was 29.6% overall and was positively correlated to the willingness to get vaccinated, ranging from 2.4% to 60.0%. Even if healthcare workers represent a heterogeneous population, most (80%) could accept the vaccination against COVID-19. Their willingness to get the vaccine increased over time and as immunization programs became available. Among hesitant professionals, the fear of adverse events was the main concern. Targeted information campaigns reassuring about adverse events may increase vaccine coverage, in a population with a strong opinion about mandatory immunization programs.
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影响因子：
3.7
作者：
Giannattasio A;Mariano M;Romano R;Chiatto F;Liguoro I;Borgia G;Guarino A;Lo Vecchio A
通讯作者：
Lo Vecchio A
影响因子：
5.5
作者：
Kuter BJ;Browne S;Momplaisir FM;Feemster KA;Shen AK;Green-McKenzie J;Faig W;Offit PA
通讯作者：
Offit PA
影响因子：
8.9
作者：
Kabamba Nzaji M;Kabamba Ngombe L;Ngoie Mwamba G;Banza Ndala DB;Mbidi Miema J;Luhata Lungoyo C;Lora Mwimba B;Cikomola Mwana Bene A;Mukamba Musenga E
通讯作者：
Mukamba Musenga E
影响因子：
6.9
作者：
Martin, C.;Montesinos, I;Vandenberg, O.
通讯作者：
Vandenberg, O.
影响因子：
5.5
作者：
Borgey, France;Henry, Liliane;Thibon, Pascal
通讯作者：
Thibon, Pascal