Differential aberrant connectivity of precuneus and anterior insula may underpin the diagnosis of schizophrenia and mood disorders.
Differential aberrant connectivity of precuneus and anterior insula may underpin the diagnosis of schizophrenia and mood disorders.
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楔前叶和前脑岛的不同异常连接可能支持精神分裂症和情绪障碍的诊断。
DOI：
10.5498/wjp.v11.i12.1274
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发表时间：
2021-12-19
影响因子：
3.1
通讯作者：
Stoyanov D
中科院分区：
文献类型：
--
作者：
Aryutova K;Paunova R;Kandilarova S;Stoyanova K;Maes MH;Stoyanov D
在过去的十年中，静息状态功能磁共振成像（rs-fMRI）主要关注脑网络，如默认模式网络（DMN）、突出网络（SN）和中央执行网络（CEN），从而更好地理解精神障碍中观察到的认知缺陷，以及其他典型的精神病理现象，如思想和行为紊乱。研究在精神分裂症（SCH）和情绪障碍中涉及的分布式脑网络的有效连接的不同模式。样本包括58名患有SCH背景下的偏执综合征（n = 26）或抑郁症(d) （n = 32）的患者，在重度抑郁症或双相情感障碍背景下。使用的方法包括rs-fMRI和随后的动态因果建模，以确定DMN、SN和CEN各节点之间的连接方向和强度。在SCH患者组中观察到从前扣带背皮层到前岛（aI）的显著兴奋连接，而在Ds患者组中观察到从楔前叶到腹外侧前额叶皮层和从楔前叶到楔前叶的抑制性连接。结果描述了与SCH和Ds相关的特定模式，并为这些疾病的潜在机制提供了更好的解释，并为鉴别诊断和精确治疗提供了信息。
Over the past decade, resting-state functional magnetic resonance imaging (rs-fMRI) has concentrated on brain networks such as the default mode network (DMN), the salience network (SN), and the central executive network (CEN), allowing for a better understanding of cognitive deficits observed in mental disorders, as well as other characteristic psychopathological phenomena such as thought and behavior disorganization. To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia (SCH) and mood disorders. The sample comprised 58 patients with either paranoid syndrome in the context of SCH (n = 26) or depressive syndrome (Ds) (n = 32), in the context of major depressive disorder or bipolar disorder. The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN, SN and CEN. A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula (aI) was observed in the SCH patient group, whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group. The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders, and inform differential diagnosis and precise treatment targeting.
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DOI：
10.1177/2470547020980681
发表时间：
2020-01
期刊：
Chronic stress (Thousand Oaks, Calif.)
影响因子：
--
作者：
Dai D;Lacadie CM;Holmes SE;Cool R;Anticevic A;Averill C;Abdallah C;Esterlis I
通讯作者：
Esterlis I
影响因子：
5.7
作者：
Di X;Biswal BB
通讯作者：
Biswal BB
影响因子：
6.7
作者：
Chamberlain, Samuel R;Sahakian, Barbara J
通讯作者：
Sahakian, Barbara J
影响因子：
13.9
作者：
Heilbronner SR;Hayden BY
通讯作者：
Hayden BY
DOI：
10.1038/npp.2009.111
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
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