Dorsal Anterior Cingulate Cortex: A Bottom-Up View.

Dorsal Anterior Cingulate Cortex: A Bottom-Up View.
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DOI:
10.1146/annurev-neuro-070815-013952
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发表时间:
2016-07-08
影响因子:
13.9
通讯作者:
Hayden BY
Hayden BY
中科院分区:
医学1区
文献类型:
--
作者:
Heilbronner SR;Hayden BY

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背侧前扣带皮层(dACC)引起了神经科学家的极大兴趣,因为它与许多重要的认知功能相关。尽管,或者可能正因为其丰富的功能,我们仍缺乏对其功能的单一全面看法。大多数研究都是自上而下地解决这个难题,使用神经影像学等综合措施。我们提供自下而上的视图,重点关注单个单元响应和解剖结构。我们总结了表征 dACC 的三种主要方法的优缺点:作为监控者、作为控制者和作为经济结构。我们认为 dACC 中的神经元专门用于表示与行为、策略或未来计划的各个方面相关的上下文或任务状态变量。我们提出 dACC 神经元通过整合不同的任务相关信息来将上下文与策略联系起来,以创建任务空间的丰富表示,并对决策和行动施加高级和抽象的控制。
The dorsal anterior cingulate cortex (dACC) has attracted great interest from neuroscientists because it is associated with so many important cognitive functions. Despite, or perhaps because of, its rich functional repertoire, we lack a single comprehensive view of its function. Most research has approached this puzzle from the top down, using aggregate measures such as neuroimaging. We provide a view from the bottom up, with a focus on singleunit responses and anatomy. We summarize the strengths and weaknesses of the three major approaches to characterizing the dACC: as a monitor, as a controller, and as an economic structure. We argue that neurons in the dACC are specialized for representing contexts, or task-state variables relevant for behavior, and strategies, or aspects of future plans. We propose that dACC neurons link contexts with strategies by integrating diverse taskrelevant information to create a rich representation of task space and exert high-level and abstract control over decision and action.
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