Molecular Characterization and Growth Association of Two Apolipoprotein A-Ib Genes in Common Carp (Cyprinus carpio).
Molecular Characterization and Growth Association of Two Apolipoprotein A-Ib Genes in Common Carp (Cyprinus carpio).
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DOI：
10.3390/ijms17091569
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发表时间：
2016-09-16
影响因子：
5.6
通讯作者：
Tong J
中科院分区：
文献类型：
--
作者：
Wang X;Yu X;Tong J
载脂蛋白A-I （ApoA-I）在功能上参与了脊椎动物脂质的运输和代谢。本研究对鲤鱼（Cyprinus carpio L.）的两种apoA-Ib亚型进行了表征。序列比较和系统发育分析表明，C. carpio ApoA-Ib在鲤科鱼类中相对保守。在胚胎发育过程中，鲤鱼apoA-Ib在多细胞期首先表达，在视神经囊泡期表达量最高。在各种组织中都发现了一种普遍存在的表达模式，其中在肝脏中尤为突出。在体重轻组和体重重组之间以及代偿生长试验中均观察到显著差异的表达水平。在鲤鱼apoA-Ib成熟mRNA中分别鉴定出17个和8个单核苷酸多态性（snp）。1和apoA-Ib。2,分别。其中两个snp (apoa - b.2-g。183A>T和apoa ib2 g。1753C - > - T)与鲤体体重和体长显著相关。这些结果表明，apoA-Ib可能在调节鲤鱼生长发育中起重要作用。
Apolipoprotein A-I (ApoA-I) is functionally involved in the transportation and metabolism of lipids in vertebrates. In this study, two isoforms of apoA-Ib in common carp (Cyprinus carpio L.) were characterized. Sequence comparison and phylogenetic analysis showed that C. carpio ApoA-Ib is relatively conserved within cyprinid fishes. During embryonic development, C. carpio apoA-Ib was first expressed at the stage of multi-cells, and the highest mRNA level was observed at the stage of optic vesicle. A ubiquitous expression pattern was detected in various tissues with extreme predominance in the liver. Significantly different expression levels were observed between light and heavy body weight groups and also in the compensatory growth test. Seventeen and eight single-nucleotide polymorphisms (SNPs) were identified in matured mRNA of the C. carpio apoA-Ib.1 and apoA-Ib.2, respectively. Two of these SNPs (apoA-Ib.2-g.183A>T and apoA-Ib.2-g.1753C>T) were significantly associated with body weight and body length in two populations of common carp. These results indicate that apoA-Ib may play an important role in the modulation of growth and development in common carp.
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DOI：
10.1007/bf01717324
发表时间：
1989-02-15
期刊：
KLINISCHE WOCHENSCHRIFT
影响因子：
--
作者：
CHAN, L
通讯作者：
CHAN, L
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.5
作者：
FERRARI, S;DRUSIANI, E;TARUGI, P
通讯作者：
TARUGI, P
影响因子：
2.4
作者：
Cunha, I.;Galante-Oliveira, S.;Castro, L. F. C.
通讯作者：
Castro, L. F. C.
DOI：
10.1152/ajpendo.00169.2007
发表时间：
2007-12-01
影响因子：
5.1
作者：
Afolabi, Paul R.;Jahoor, Farook;Elia, Marinos
通讯作者：
Elia, Marinos