Lymphocyte measures in treatment-naïve 13-15-year old adolescents with alcohol use disorders.
Lymphocyte measures in treatment-naïve 13-15-year old adolescents with alcohol use disorders.
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DOI：
10.1016/j.alcohol.2011.02.307
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Carey PD
中科院分区：
文献类型：
--
作者：
Naude CE;Bouic P;Senekal M;Kidd M;Ferrett HL;Fein G;Carey PD
许多青少年长期接触危险水平的酒精。这可能是健康结果的重要预测因素，包括与免疫力相关的健康结果。我们评估了开普敦重度饮酒青少年（符合 DSM-IV 酒精依赖标准）和轻度/不饮酒控制青少年的物质使用和生化免疫学参数。酒精依赖（AD）参与者的终生酒精剂量（以标准酒精单位测量）比对照组高出几个数量级。所有青少年 AD 都有“仅周末”饮酒方式。 AD 组被选择代表相对“纯粹”的 AD，使用最少的其他药物且没有精神病诊断。有了这些狭窄的参数，我们发现 AD 青少年与对照组相比淋巴细胞减少，循环 CD3+、CD4+ 和 CD8+ T 淋巴细胞的绝对平均数量显着较低。结论是，我们发现，青少年 AD 患者在周末酗酒、过量饮酒但没有合并药物或精神疾病的情况下，出现淋巴细胞减少症的风险可能会增加。这种酒精滥用可能会降低免疫系统的能力，从而增加传染病的易感性（包括结核病和艾滋病毒）。酒精与其他记录在案的高风险活动的复杂相互作用可能会进一步加剧健康风险。
Many adolescents have chronic exposure to hazardous levels of alcohol. This is likely to be a significant predictor of health outcomes, including those related to immunity. We assessed substance use and biochemical immunological parameters in heavy drinking adolescents (meeting DSM-IV criteria for alcohol dependence) and light/non-drinking control adolescents in Cape Town. Lifetime alcohol dose, measured in standard units of alcohol, was orders of magnitude higher in alcohol dependent (AD) participants than controls. All adolescent AD had a ‘weekends-only’ style of alcohol consumption. The AD group was chosen to represent relatively ‘pure’ AD, with minimal other drug use and no psychiatric diagnoses. With these narrow parameters in place, we found that AD adolescents were lymphopenic compared to controls, with significantly lower mean numbers of absolute circulating CD3+, CD4+ and CD8+ T-lymphocytes. Upon conclusion, we found that adolescent AD individuals with excessive alcohol intake, in a weekend binge-drinking style but without comorbid drug or psychiatric disorders, may be at increased risk of lymphopenia. This alcohol misuse may increase infectious disease susceptibility (including TB and HIV) by reducing immune system capabilities. Complex interactions of alcohol with other documented high-risk activities may further compound health risks.
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影响因子：
2.8
作者：
Lim, Wei-Yen;Fong, Chee Weng;Chew, Suok Kai
通讯作者：
Chew, Suok Kai
影响因子：
3.2
作者：
Kutscher, S;Heise, DJ;Exton, MS
通讯作者：
Exton, MS
DOI：
10.1111/j.1530-0277.1989.tb00359.x
发表时间：
1989-08-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
MEADOWS, GG;BLANK, SE;DUNCAN, DD
通讯作者：
DUNCAN, DD
影响因子：
4.6
作者：
Cook, RT;Waldschmidt, TJ;McLatchie, K
通讯作者：
McLatchie, K
影响因子：
7.6
作者：
Flisher, AJ;Parry, CDH;Lombard, C
通讯作者：
Lombard, C