Common and distinct neural mechanisms of attentional switching and response conflict.
Common and distinct neural mechanisms of attentional switching and response conflict.
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DOI：
10.1016/j.brainres.2012.06.013
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发表时间：
2012-08-21
期刊：
影响因子：
2.9
通讯作者：
Gold BT
中科院分区：
文献类型：
--
作者：
Kim C;Johnson NF;Gold BT
人类克服强势行为和在任务之间灵活切换的能力是认知控制的基石。功能神经成像显示，不同的大脑区域参与了这些认知控制过程中的每一个。然而，注意力转换和反应冲突在多大程度上依赖于共同或不同的神经机制仍不清楚。目前的研究使用事件相关功能磁共振成像(FMRI)和完全随机的2×2设计来检验反应冲突和注意转换的神经关联。我们操纵了Stroop任务的箭头词版本，以测量在单个任务决定的背景下，对一组常见刺激的反应中的冲突和转换。在这些常见的条件下，行为和成像数据都显示出显著的冲突和转换的主效应，但没有交互作用。然而，联合分析确定了参与转换和反应冲突的额叶区域，包括背侧前扣带回皮质(DACC)和左下额交界处。此外，连接性分析还表明，任务相关的功能连接模式在dACC和颞叶下皮质之间用于注意转换，在dACC和后顶叶皮质之间用于反应冲突。这些结果表明，大脑利用共享的额叶区域，但可以动态调节其中一些区域的连接模式，以处理注意力切换和反应冲突。
The human capacities for overcoming prepotent actions and flexibly switching between tasks represent cornerstones of cognitive control. Functional neuroimaging has implicated a diverse set of brain regions contributing to each of these cognitive control processes. However, the extent to which attentional switching and response conflict draw on shared or distinct neural mechanisms remains unclear. The current study examined the neural correlates of response conflict and attentional switching using event-related functional magnetic resonance imaging (fMRI) and a fully randomized 2×2 design. We manipulated an arrow-word version of the Stroop task to measure conflict and switching in the context of a single task decision, in response to a common set of stimuli. Under these common conditions, both behavioral and imaging data showed significant main effects of conflict and switching but no interaction. However, conjunction analyses identified frontal regions involved in both switching and response conflict, including the dorsal anterior cingulate cortex (dACC) and left inferior frontal junction. In addition, connectivity analyses demonstrated task-dependent functional connectivity patterns between dACC and inferior temporal cortex for attentional switching and between dACC and posterior parietal cortex for response conflict. These results suggest that the brain makes use of shared frontal regions, but can dynamically modulate the connectivity patterns of some of those regions, to deal with attentional switching and response conflict.
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DOI：
10.1073/pnas.96.14.8301
发表时间：
1999-07-06
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.222193299
发表时间：
2002-10-29
影响因子：
11.1
作者：
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通讯作者：
Berman, KF