Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury.
Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury.
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DOI：
10.1002/acn3.51855
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发表时间：
2023-09
影响因子：
5.3
通讯作者：
Boakye, Maxwell
中科院分区：
文献类型：
--
作者：
Ahmed, Rakib Uddin;Medina-Aguinaga, Daniel;Adams, Shawns;Knibbe, Chase A.;Morgan, Monique;Gibson, Destiny;Kim, Joo-won;Sharma, Mayur;Chopra, Manpreet;Davison, Steven;Sherwood, Leslie C.;Negahdar, M. J.;Bert, Robert;Ugiliweneza, Beatrice;Hubscher, Charles;Budde, Matthew D.;Xu, Junqian;Boakye, Maxwell
在尤卡坦小型猪脊髓损伤（SCI）模型中，与常规磁共振成像（MRI）和扩散张量成像（DTI）相比，探索滤波弥散加权成像（fDWI）作为长期运动和尿动力学（UD）结局的预测因子。此外，使用损伤上方和下方的D波测量神经组织的电导率，以评估fDWI和D波数据之间的相关性。11只T8-T10节段挫伤SCI的小型猪在3 T 4 h进行MRI。脊髓损伤后从感兴趣区分析中提取的参数包括损伤部位fDWI的Daxial、损伤部位沿着DTI的各向异性分数和径向扩散率，以及T2加权图像损伤部位的水肿长度和脊髓宽度。在SCI前和SCI后每周通过猪胸部损伤行为量表（PTIBS）评估运动恢复情况，并在SCI前和SCI后12周进行UD。在SCI之前和之后立即记录D波潜伏期和振幅差异。根据SCI后第12周的PTIBS（p < 0.0001），发现了两组猪，并将其标记为“较差”和“良好”恢复。D波振幅在损伤下方降低，在损伤上方升高。SCI前后UD结果发生了显著变化。T2加权图像的常规MRI指标与弥散MRI指标显著相关。SCI后不久，损伤中心的轴向减少了50%以上，并区分了良好和不良的运动恢复和UD结果。与小动物研究类似，SCI后急性成像的fDWI是大型动物功能结局的有希望的预测因子。
To explore filtered diffusion‐weighted imaging (fDWI), in comparison with conventional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), as a predictor for long‐term locomotor and urodynamic (UD) outcomes in Yucatan minipig model of spinal cord injury (SCI). Additionally, electrical conductivity of neural tissue using D‐waves above and below the injury was measured to assess correlations between fDWI and D‐waves data. Eleven minipigs with contusion SCI at T8‐T10 level underwent MRI at 3T 4 h. post‐SCI. Parameters extracted from region of interest analysis included Daxial from fDWI at injury site, fractional anisotropy and radial diffusivity from DTI above the injury site along with measures of edema length and cord width at injury site from T2‐weighted images. Locomotor recovery was assessed pre‐ and weekly post‐SCI through porcine thoracic injury behavior scale (PTIBS) and UD were performed pre‐ and at 12 weeks of SCI. D‐waves latency and amplitude differences were recorded before and immediately after SCI. Two groups of pigs were found based on the PTIBS at week 12 (p < 0.0001) post‐SCI and were labeled “poor” and “good” recovery. D‐waves amplitude decreased below injury and increased above injury. UD outcomes pre/post SCI changed significantly. Conventional MRI metrics from T2‐weighted images were significantly correlated with diffusion MRI metrics. Daxial at injury epicenter was diminished by over 50% shortly after SCI, and it differentiated between good and poor locomotor recovery and UD outcomes. Similar to small animal studies, fDWI from acute imaging after SCI is a promising predictor for functional outcomes in large animals.
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影响因子：
2.2
作者：
Gross O;Leitner L;Rasenack M;Schubert M;Kessler TM
通讯作者：
Kessler TM
影响因子：
3.7
作者：
Freund P;Schneider T;Nagy Z;Hutton C;Weiskopf N;Friston K;Wheeler-Kingshott CA;Thompson AJ
通讯作者：
Thompson AJ
影响因子：
4.2
作者：
Cheran, Sendhil;Shanmuganathan, Kathirkamanathan;Gullapalli, Rao P.
通讯作者：
Gullapalli, Rao P.
影响因子：
4.2
作者：
Koskinen, Eerika;Brander, Antti;Ohman, Juha
通讯作者：
Ohman, Juha
影响因子：
2.9
作者：
Del Cerro P;Rodríguez-De-Lope Á;Collazos-Castro JE
通讯作者：
Collazos-Castro JE