Couples' urinary bisphenol A and phthalate metabolite concentrations and the secondary sex ratio.
Couples' urinary bisphenol A and phthalate metabolite concentrations and the secondary sex ratio.
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夫妻的尿苯酚A和邻苯二甲酸酯代谢产物浓度和继发性别比例。
DOI：
10.1016/j.envres.2014.11.011
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发表时间：
2015-02
影响因子：
8.3
通讯作者：
Louis, Germaine M. Buck
中科院分区：
文献类型：
--
作者：
Bae, Jisuk;Kim, Sungduk;Kannan, Kurunthachalam;Louis, Germaine M. Buck
由于有限的研究集中在非持久性化学品作为影响人类性别选择的外源性因素，本研究旨在评估尿双酚A（BPA）和邻苯二甲酸酯代谢物浓度与第二性比（SSR）的关系，SSR定义为男性与女性活产的比例。目前的分析仅限于生育力和环境（LIFE）纵向调查研究中的单胎活产（n=220，43.9%），该研究招募了停止避孕的夫妇，并在尝试怀孕和分娩时随访了那些怀孕的夫妇。使用改良的泊松回归模型解释潜在的混杂因素，我们估计了男性出生的相对风险（RR），每个标准差变化的对数转换的母亲，父亲和夫妇的尿液BPA和邻苯二甲酸酯代谢物浓度（ng/mL）时测量入组。当母亲和父亲的化学浓度联合建模，父亲BPA（RR，0.77; 95%置信区间[CI]，0.62-0.95）和邻苯二甲酸单异丁酯（RR，0.82; 95% CI，0.67-1.00）与女性的过量显着相关。母亲BPA（RR，1.16; 95% CI，1.03-1.31），邻苯二甲酸单异丁酯（RR，1.28; 95% CI，1.06-1.54），邻苯二甲酸单苄酯（RR，1.31; 95% CI，1.08-1.58）和邻苯二甲酸单正丁酯（RR，1.24; 95% CI，1.01-1.51）与男性过量显著相关。这些研究结果强调不同的模式SSR与父母的曝光。鉴于以前没有进行过调查，这些非持久性化学品与安全部门改革之间的伙伴特定联系需要进一步证实。
With limited research focusing on non-persistent chemicals as exogenous factors affecting human sex selection, this study aimed to evaluate the association of urinary bisphenol A (BPA) and phthalate metabolite concentrations with the secondary sex ratio (SSR), defined as the ratio of male to female live births. The current analysis is limited to singleton live births (n=220, 43.9%) from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study, which enrolled couples upon discontinuing contraception and followed while trying for pregnancy and through delivery those achieving pregnancy. Using modified Poisson regression models accounting for potential confounders, we estimated the relative risks (RRs) of a male birth per standard deviation change in the log-transformed maternal, paternal, and couple urinary BPA and 14 phthalate metabolite concentrations (ng/mL) measured upon enrollment. When maternal and paternal chemical concentrations were modeled jointly, paternal BPA (RR, 0.77; 95% confidence interval [CI], 0.62–0.95) and mono-isobutyl phthalate (RR, 0.82; 95% CI, 0.67–1.00) were significantly associated with a female excess. Contrarily, maternal BPA (RR, 1.16; 95% CI, 1.03–1.31), mono-isobutyl phthalate (RR, 1.28; 95% CI, 1.06–1.54), mono-benzyl phthalate (RR, 1.31; 95% CI, 1.08–1.58), and mono-n-butyl phthalate (RR, 1.24; 95% CI, 1.01–1.51) were significantly associated with a male excess. These findings underscore varying patterns for the SSR in relation to parental exposures. Given the absence of previous investigation, these partner-specific associations of non-persistent chemicals with the SSR need future corroboration.
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