Epigenetic transgenerational effects of endocrine disruptors on male reproduction.
Epigenetic transgenerational effects of endocrine disruptors on male reproduction.
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DOI：
10.1055/s-0029-1237428
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发表时间：
2009-09
影响因子：
2.7
通讯作者：
Skinner MK
中科院分区：
文献类型：
--
作者：
Guerrero-Bosagna CM;Skinner MK
内分泌干扰化学品通常作为类固醇受体信号传导拮抗剂或激动剂，影响发育，促进成人发病。在男性生殖道发育初期暴露于内分泌干扰物会干扰正常的激素信号和男性生殖器官的形成。特别是，暴露于内分泌干扰物乙烯氯唑啉会促进成年发病疾病状态的跨代传播，如男性不育、肿瘤发生频率增加、前列腺疾病、肾脏疾病和随着男性年龄增长而发展的免疫异常。生殖系的表观遗传变化将参与这些诱导表型的跨代传递。然而，其他研究也报告了诱导的表观遗传变化的跨代传递，而不改变生殖系。在这里，我们提出了一个命名法，以帮助澄清两种情况下的跨代表观遗传传递。一个内在的表观遗传的跨代过程将需要一个生殖系的参与，在生殖细胞表观基因组的永久性改变，只有一个暴露于环境因素。外源性表观遗传跨代过程将涉及体细胞组织中的表观遗传改变，并且需要在每一代暴露以维持跨代表型。
Endocrine-disrupting chemicals generally function as steroid receptor signaling antagonists or agonists that influence development to promote adult-onset disease. Exposure to the endocrine disruptors during the initiation of male reproductive tract development interferes with the normal hormonal signaling and formation of male reproductive organs. In particular, exposure to the endocrine disruptor vinclozolin promotes transgenerational transmission of adult-onset disease states such as male infertility, increased frequencies of tumors, prostate disease, kidney diseases, and immune abnormalities that develop as males age. An epigenetic change in the germ line would be involved in the transgenerational transmission of these induced phenotypes. Nevertheless, other studies have also reported transgenerational transmission of induced epigenetic changes, without altering the germ line. Here we propose a nomenclature to help clarify both cases of transgenerational epigenetic transmission. An intrinsic epigenetic transgenerational process would require a germ-line involvement, a permanent alteration in the germ cell epigenome, and only one exposure to the environmental factor. An extrinsic epigenetic transgenerational process would involve an epigenetic alteration in a somatic tissue and require exposure at each generation to maintain the transgenerational phenotype.
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DOI：
10.1073/pnas.0610410104
发表时间：
2007-04-03
影响因子：
11.1
作者：
Crews, David;Gore, Andrea C.;Skinner, Michael K.
通讯作者：
Skinner, Michael K.
疾病病因中的环境暴露和基因调节。
影响因子：
10.4
作者：
Edwards, Thea M.;Myers, John Peterson
通讯作者：
Myers, John Peterson
影响因子：
2.9
作者：
Chen, ZX;Riggs, AD
通讯作者：
Riggs, AD
影响因子：
4.8
作者：
Anway, Matthew D.;Leathers, Charles;Skinner, Michael K.
通讯作者：
Skinner, Michael K.
影响因子：
4.4
作者：
Anway, Matthew D.;Rekow, Stephen S.;Skinner, Michael K.
通讯作者：
Skinner, Michael K.