A Connectome-wide Functional Signature of Transdiagnostic Risk for Mental Illness.
A Connectome-wide Functional Signature of Transdiagnostic Risk for Mental Illness.
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DOI：
10.1016/j.biopsych.2018.03.012
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发表时间：
2018-09-15
影响因子：
10.6
通讯作者：
Hariri AR
中科院分区：
文献类型：
--
作者：
Elliott ML;Romer A;Knodt AR;Hariri AR
合并症的高发病率，共同的风险和重叠的治疗机制，导致精神病理学研究对跨诊断的集群症状的调查。一个有影响力的框架通过一个单一的一般因素来解释这些转诊断现象，有时被称为“p”因素，与所有常见形式的精神疾病的风险相关。在这里，我们建立在过去的研究，确定独特的结构神经相关的p因子进行数据驱动的分析连接体广泛的内在功能连接（n = 605）。我们证明，较高的p因子得分和常见精神疾病的相关风险映射到视觉关联皮层和额顶叶和默认模式网络之间的超连通性。这些结果提供了初步证据，即常见形式的精神疾病的转诊断风险与视觉关联皮层和支持执行控制和自我参照过程的网络之间的低效连接体广泛内在连接模式有关，这些网络通常在分类障碍中受损。
High rates of comorbidity, shared risk, and overlapping therapeutic mechanisms have led psychopathology research towards transdiagnostic dimensional investigations of clustered symptoms. One influential framework accounts for these transdiagnostic phenomena through a single general factor, sometimes referred to as the ‘p’ factor, associated with risk for all common forms of mental illness. Here we build on past research identifying unique structural neural correlates of the p factor by conducting a data-driven analysis of connectome wide intrinsic functional connectivity (n = 605). We demonstrate that higher p factor scores and associated risk for common mental illness maps onto hyper-connectivity between visual association cortex and both frontoparietal and default mode networks. These results provide initial evidence that the transdiagnostic risk for common forms of mental illness is associated with patterns of inefficient connectome wide intrinsic connectivity between visual association cortex and networks supporting executive control and self-referential processes, networks which are often impaired across categorical disorders.
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影响因子：
5.7
作者：
Calhoun, VD;Adali, T;Pearlson, GD
通讯作者：
Pearlson, GD
DOI：
10.1177/1073858414525995
发表时间：
2014-12
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Cole MW;Repovš G;Anticevic A
通讯作者：
Anticevic A
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Desseilles, Martin;Schwartz, Sophie;Phillips, Christophe
通讯作者：
Phillips, Christophe
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.