Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population.
Influent factors of gestational vitamin D deficiency and its relation to an increased risk of preterm delivery in Chinese population.
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中国人群妊娠期维生素D缺乏的影响因素及其与早产风险增加的关系
DOI：
10.1038/s41598-018-21944-3
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发表时间：
2018-02-26
影响因子：
4.6
通讯作者：
Xu DX
中科院分区：
文献类型：
--
作者：
Chen YH;Fu L;Hao JH;Wang H;Zhang C;Tao FB;Xu DX
维生素D缺乏症（VDD）与不良妊娠结局有关。为探讨妊娠期VDD的影响因素及其与早产发生率的关系，共收集3598对符合条件的母婴对。941例孕妇血清25（OH）D浓度充足，1260例不足，1397例不足。进一步分析表明，VDD在冬季比其他季节更普遍。体重过轻而非超重是妊娠VDD的危险因素。使用多种维生素可降低妊娠VDD的风险。有趣的是，在VDD受试者中有8.23%的早产儿（校正RR：4.02; 95% CI：2.33，6.92），在妊娠期维生素D不足（VDD）受试者中有3.81%的早产儿（校正RR：2.07; 95% CI：1.16，3.71）。此外，在VDD受试者中有2.59%的早产儿（校正RR：2.97; 95% CI：1.41，6.24），在VDD受试者中有0.49%（校正RR：0.54; 95% CI：0.19，1.51）。VDD受试者中晚期早产的发生率为5.64%（校正RR：3.90; 95% CI：2.26，6.72），VDD受试者中晚期早产的发生率为3.32%（校正RR：2.09; 95% CI：1.17，3.74）。总之，孕前BMI、季节性和多种维生素的使用是妊娠期维生素D状况的影响因素。在中国人群中，吉西他滨VDD与早产风险增加相关。
Gestational vitamin D deficiency (VDD) has been linked with adverse pregnant outcomes. To investigate influent factors of gestational VDD and its relation to the incidence of preterm delivery, total 3598 eligible mother-and-singleton-offspring pairs were recruited. For serum 25(OH)D concentration, 941 pregnant women were sufficient, 1260 insufficient, and 1397 deficient. Further analysis showed that VDD was more prevalent in winter than in other seasons. Underweight but not overweight was a risk factor for gestational VDD. Multivitamin use reduced risk of gestational VDD. Interestingly, 8.23% delivered preterm infants among subjects with VDD (adjusted RR: 4.02; 95% CI: 2.33, 6.92) and 3.81% among subjects with gestational vitamin D insufficiency (VDI) (adjusted RR: 2.07; 95% CI: 1.16, 3.71). Moreover, 2.59% delivered early preterm infants among subjects with VDD (adjusted RR: 2.97; 95% CI: 1.41, 6.24) and 0.49% among subjects with VDI (adjusted RR: 0.54; 95% CI: 0.19, 1.51). The incidence of late preterm delivery was 5.64% among subjects with VDD (adjusted RR: 3.90; 95% CI: 2.26, 6.72) and 3.32% among subjects with VDI (adjusted RR: 2.09; 95% CI: 1.17, 3.74). In conclusion, pre-pregnancy BMI, seasonality and multivitamin use are influent factors of gestational vitamin D status. Gestational VDD is associated with an increased risk of preterm delivery in Chinese population.
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影响因子：
2.7
作者：
Harms, Lauren R.;Eyles, Darryl W.;Burne, Thomas H. J.
通讯作者：
Burne, Thomas H. J.
影响因子：
4.6
作者：
Chao CT;Lee SY;Yang WS;Yen CJ;Chiang CK;Huang JW;Hung KY
通讯作者：
Hung KY
影响因子：
4.2
作者：
Bodnar, Lisa M.;Catov, Janet M.;Simhan, Hyagriv N.
通讯作者：
Simhan, Hyagriv N.
影响因子：
3.7
作者：
McDonnell SL;Baggerly KA;Baggerly CA;Aliano JL;French CB;Baggerly LL;Ebeling MD;Rittenberg CS;Goodier CG;Mateus Niño JF;Wineland RJ;Newman RB;Hollis BW;Wagner CL
通讯作者：
Wagner CL
影响因子：
5.9
作者：
Qin LL;Lu FG;Yang SH;Xu HL;Luo BA
通讯作者：
Luo BA