Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.
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DOI：
10.1016/j.immuni.2014.03.005
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发表时间：
2014-04-17
期刊：
影响因子：
32.4
通讯作者：
Ivanov, Ivaylo I.
中科院分区：
文献类型：
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作者：
Goto, Yoshiyuki;Panea, Casandra;Nakato, Gaku;Cebula, Anna;Lee, Carolyn;Diez, Marta Galan;Laufer, Terri M.;Ignatowicz, Leszek;Ivanov, Ivaylo I.
共生微生物区系如何有助于屏障表面的免疫细胞稳态，目前还知之甚少。固有层(Lp)辅助性T细胞(Th17)参与黏膜保护，由共生节段性丝状细菌(SFB)诱导。在这里，我们表明肠树突状细胞(DC)对MHCII依赖的SFB抗原的提呈对于Th17细胞的诱导至关重要。CD11c+细胞表达MHCII是SFB诱导Th17细胞分化的必要条件和充分条件。大多数SFB诱导的Th17细胞以MHCII依赖的方式识别SFB。SFB在LP中局部激发和诱导Th17细胞，在缺乏次级淋巴器官的小鼠中正常诱导Th17细胞。第三组先天淋巴样细胞(ILCs)中MHCII缺乏导致非SFB依赖的Th17细胞分化增加，揭示了其他先天细胞的重要性。我们的结果概括了DC和ILCs在调节肠道Th17细胞稳态中的复杂作用
How commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly understood. Lamina propria (LP) T helper 17 (Th17) cells participate in mucosal protection and are induced by commensal segmented filamentous bacteria (SFB). Here we show that MHCII-dependent antigen presentation of SFB antigens by intestinal dendritic cells (DCs) is crucial for Th17 cell induction. Expression of MHCII on CD11c+ cells was necessary and sufficient for SFB-induced Th17 cell differentiation. Most SFB-induced Th17 cells recognized SFB in an MHCII-dependent manner. SFB primed and induced Th17 cells locally in the LP and Th17 cell induction occurred normally in mice lacking secondary lymphoid organs. The importance of other innate cells was unveiled by the finding that MHCII deficiency in group 3 innate lymphoid cells (ILCs) resulted in an increase in SFB independent Th17 cell differentiation. Our results outline the complex role of DCs and ILCs in the regulation of intestinal Th17 cell homeostasis
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影响因子：
56.9
作者：
GRUSBY, MJ;JOHNSON, RS;GLIMCHER, LH
通讯作者：
GLIMCHER, LH
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
DOI：
10.1084/jem.20062648
发表时间：
2007-07-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Caton ML;Smith-Raska MR;Reizis B
通讯作者：
Reizis B
影响因子：
30.3
作者：
Ivanov II;Honda K
通讯作者：
Honda K
影响因子：
64.8
作者：
通讯作者：
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