Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes.
Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes.
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DOI：
10.1186/1475-2840-12-67
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发表时间：
2013-04-17
影响因子：
9.3
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Tong G;Wang N;Leng J;Tong X;Shen Y;Yang J;Ye X;Zhou L;Zhou Y
脂联素是一种促进胰岛素作用的脂肪因子，具有抗动脉粥样硬化作用。本研究旨在探讨脂联素基因常见单核苷酸多态性（single nucleotide polymorphisms，SNPs）对血浆脂联素水平的影响及其与2型糖尿病患者冠状动脉病变（coronary artery disease，CAD）风险和冠状动脉病变严重程度的关系。对1110例2型糖尿病合并或不合并CAD的受试者进行了11个标签SNP的基因分型。采用Taqman聚合酶链反应方法检测脂联素基因的变异。采用双抗体夹心酶联免疫吸附法测定血浆脂联素浓度。采用冠状动脉造影Gensini评分和Sullivan程度评分评估冠状动脉粥样硬化的严重程度和范围。在11个SNPs中，SNP rs 266729的次要G等位基因与CAD的高风险显著相关（调整协变量后的风险比（95%CI）= 1.49（1.10 - 2.16），P = 0.022）。多因素Logistic回归分析显示，SNP rs 266729是冠心病的独立危险因素。多元线性回归分析显示，rs 266729（β =-0.101，P < 0.0001），rs182052（β =-0.044，P = 0.0035）和rs 1501299（β = 0.073，P < 0.0001）与脂联素水平显著相关，SNP rs 266729的G等位基因的Gensini评分（β = 0.139，P < 0.001）和Sullivan Extent评分（β = 0.107，P < 0.001）均高于其他等位基因。单倍型分析显示病例组和对照组的单倍型分布不同（P = 0.0003），rs 266729、rs 182052和rs 1501299的两种常见单倍型GGG和GAG在杂合子中与心血管风险增加3倍以上相关（比值比（95%CI）=3.39（1.83 ~ 6.30），P = 0.0001）。在我们的人群中，脂联素基因的遗传变异影响血浆脂联素水平，其中之一是2型糖尿病CAD易感性及其血管造影严重程度的重要决定因素。本研究为脂联素在CAD发生发展中的作用提供了进一步的证据。
Adiponectin, an adipokine facilitating insulin action, has antiatherogenic effects. This study investigated whether common single nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with the risk of coronary artery disease (CAD) and its angiographical severity in type 2 diabetes in Chinese population. 11 tagging SNPs were genotyped in 1110 subjects with or without CAD in type 2 diabetes. Variants of adiponectin gene were determined by Taqman polymerase chain reaction method. The plasma adiponectin concentrations were measured by sandwich enzyme-linked immunosorbent assay. The severity and extent of coronary atherosclerosis were assessed using the angiographic Gensini score and Sullivan Extent score. Among the 11 SNPs, the minor G allele of SNP rs266729 was significantly associated with higher odds of CAD (odds ratio (95% CI) = 1.49 (1.10 - 2.16), P = 0.022) after adjusting for covariates. In stepwise multivariate logistic regression, SNP rs266729 was a significant independent factor of CAD. Multivariate linear regression analysis revealed that rs266729 (β = −0.101, P < 0.0001), rs182052 (β = −0.044, P = 0.0035), and rs1501299 (β = 0.073, P < 0.0001) were significantly associated with adiponectin level, and also indicated that the minor G allele of SNP rs266729 had higher Gensini score (β = 0.139, P < 0.001) and Sullivan Extent score (β = 0.107, P < 0.001). Haplotypes analysis revealed different haplotype distributions in case and control subjects (P = 0.0003), with two common haplotypes GGG and GAG of the rs266729, rs182052, and rs1501299 being associated in heterozygotes with a greater than threefold increase in cardiovascular risk (odds ratio (95% CI)=3.39 (1.83 - 6.30), P = 0.0001). In our population, genetic variants in the adiponectin gene influence plasma adiponectin levels, and one of them is a strong determinant of CAD susceptibility and its angiographical severity in type 2 diabetes. This study has provided further evidence for a role of adiponectin in the development of CAD.
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影响因子：
2
作者：
Jung, Chan-Hee;Rhee, Eun-Jung;Park, Jung-Roe
通讯作者：
Park, Jung-Roe
影响因子：
64.8
作者：
Frazer, Kelly A.;Ballinger, Dennis G.;Cox, David R.;Hinds, David A.;Stuve, Laura L.;Gibbs, Richard A.;Belmont, John W.;Boudreau, Andrew;Hardenbol, Paul;Leal, Suzanne M.;Pasternak, Shiran;Wheeler, David A.;Willis, Thomas D.;Yu, Fuli;Yang, Huanming;Zeng, Changqing;Gao, Yang;Hu, Haoran;Hu, Weitao;Li, Chaohua;Lin, Wei;Liu, Siqi;Pan, Hao;Tang, Xiaoli;Wang, Jian;Wang, Wei;Yu, Jun;Zhang, Bo;Zhang, Qingrun;Zhao, Hongbin;Zhao, Hui;Zhou, Jun;Gabriel, Stacey B.;Barry, Rachel;Blumenstiel, Brendan;Camargo, Amy;Defelice, Matthew;Faggart, Maura;Goyette, Mary;Gupta, Supriya;Moore, Jamie;Nguyen, Huy;Onofrio, Robert C.;Parkin, Melissa;Roy, Jessica;Stahl, Erich;Winchester, Ellen;Ziaugra, Liuda;Altshuler, David;Shen, Yan;Yao, Zhijian;Huang, Wei;Chu, Xun;He, Yungang;Jin, Li;Liu, Yangfan;Shen, Yayun;Sun, Weiwei;Wang, Haifeng;Wang, Yi;Wang, Ying;Xiong, Xiaoyan;Xu, Liang;Waye, Mary M. Y.;Tsui, Stephen K. W.;Wong, J. Tze-Fei;Galver, Luana M.;Fan, Jian-Bing;Gunderson, Kevin;Murray, Sarah S.;Oliphant, Arnold R.;Chee, Mark S.;Montpetit, Alexandre;Chagnon, Fanny;Ferretti, Vincent;Leboeuf, Martin;Olivier, Jean-Franccois;Phillips, Michael S.;Roumy, Stephanie;Sallee, Clementine;Verner, Andrei;Hudson, Thomas J.;Kwok, Pui-Yan;Cai, Dongmei;Koboldt, Daniel C.;Miller, Raymond D.;Pawlikowska, Ludmila;Taillon-Miller, Patricia;Xiao, Ming;Tsui, Lap-Chee;Mak, William;Song, You Qiang;Tam, Paul K. H.;Nakamura, Yusuke;Kawaguchi, Takahisa;Kitamoto, Takuya;Morizono, Takashi;Nagashima, Atsushi;Ohnishi, Yozo;Sekine, Akihiro;Tanaka, Toshihiro;Tsunoda, Tatsuhiko;Deloukas, Panos;Bird, Christine P.;Delgado, Marcos;Dermitzakis, Emmanouil T.;Gwilliam, Rhian;Hunt, Sarah;Morrison, Jonathan;Powell, Don;Stranger, Barbara E.;Whittaker, Pamela;Bentley, David R.;Daly, Mark J.;de Bakker, Paul I. W.;Barrett, Jeff;Chretien, Yves R.;Maller, Julian;McCarroll, Steve;Patterson, Nick;Pe'er, Itsik;Price, Alkes;Purcell, Shaun;Richter, Daniel J.;Sabeti, Pardis;Saxena, Richa;Schaffner, Stephen F.;Sham, Pak C.;Varilly, Patrick;Altshuler, David;Stein, Lincoln D.;Krishnan, Lalitha;Smith, Albert Vernon;Tello-Ruiz, Marcela K.;Thorisson, Gudmundur A.;Chakravarti, Aravinda;Chen, Peter E.;Cutler, David J.;Kashuk, Carl S.;Lin, Shin;Abecasis, Goncalo R.;Guan, Weihua;Li, Yun;Munro, Heather M.;Qin, Zhaohui Steve;Thomas, Daryl J.;McVean, Gilean;Auton, Adam;Bottolo, Leonardo;Cardin, Niall;Eyheramendy, Susana;Freeman, Colin;Marchini, Jonathan;Myers, Simon;Spencer, Chris;Stephens, Matthew;Donnelly, Peter;Cardon, Lon R.;Clarke, Geraldine;Evans, David M.;Morris, Andrew P.;Weir, Bruce S.;Tsunoda, Tatsuhiko;Johnson, Todd A.;Mullikin, James C.;Sherry, Stephen T.;Feolo, Michael;Skol, Andrew
通讯作者：
Skol, Andrew
影响因子：
3.5
作者：
Lacquemant, C;Froguel, P;Ruiz, J
通讯作者：
Ruiz, J
影响因子：
8.2
作者：
Han, L. Y.;Wu, Q. H.;Sun, H.
通讯作者：
Sun, H.
影响因子：
6.9
作者：
Ling, Hua;Waterworth, Dawn M.;Stirnadel, Heide A.;Pollin, Toni I.;Barter, Philip J.;Kesaniemi, Y. Antero;Mahley, Robert W.;McPherson, Ruth;Waeber, Gerard;Bersot, Thomas P.;Cohen, Jonathan C.;Grundy, Scott M.;Mooser, Vincent E.;Mitchell, Braxton D.
通讯作者：
Mitchell, Braxton D.