Increasing iron and zinc in pre-menopausal women and its effects on mood and cognition: a systematic review.
Increasing iron and zinc in pre-menopausal women and its effects on mood and cognition: a systematic review.
复制标题
DOI：
10.3390/nu6115117
复制
发表时间：
2014-11-14
期刊：
影响因子：
5.9
通讯作者：
Byrne LK
中科院分区：
文献类型：
--
作者：
Lomagno KA;Hu F;Riddell LJ;Booth AO;Szymlek-Gay EA;Nowson CA;Byrne LK
铁和锌是必需的矿物质，通常存在于类似的食物来源中。除了明显的缺铁和缺锌状态的不利影响外，铁不足还与情绪和认知障碍有关。本文综述了目前有关铁或锌补充剂及其对绝经前妇女情绪或认知的影响的文献。检索包括MEDLINE complete、Excerpta Medica Database（EMBASE）、psychINFO、psychARTICLES、pubMED、ProQuest Health and Medical Complete Academic Search complete、Scopus和ScienceDirect。10项随机对照试验和1项非随机对照试验符合纳入标准。七项研究发现，补铁后情绪和认知方面有所改善。在7项研究中，补充铁似乎可以改善12至55岁参与者的记忆力和智力，无论参与者最初是铁不足还是缺铁伴贫血。该综述还发现了三项对照研究提供的证据表明，锌补充剂作为抑郁症状的治疗，既作为诊断为重度抑郁症的个体的传统抗抑郁治疗的辅助治疗，又作为绝经前缺锌妇女的治疗方法。总体而言，目前的文献表明，改善锌状态对增强认知和情感功能有积极影响。然而，需要进一步的研究，包括设计良好的随机对照试验，以确定改善铁和锌状态对情绪和认知的影响。
Iron and zinc are essential minerals often present in similar food sources. In addition to the adverse effects of frank iron and zinc-deficient states, iron insufficiency has been associated with impairments in mood and cognition. This paper reviews current literature on iron or zinc supplementation and its impact on mood or cognition in pre-menopausal women. Searches included MEDLINE complete, Excerpta Medica Database (EMBASE), psychINFO, psychARTICLES, pubMED, ProQuest Health and Medical Complete Academic Search complete, Scopus and ScienceDirect. Ten randomized controlled trials and one non-randomized controlled trial were found to meet the inclusion criteria. Seven studies found improvements in aspects of mood and cognition after iron supplementation. Iron supplementation appeared to improve memory and intellectual ability in participants aged between 12 and 55 years in seven studies, regardless of whether the participant was initially iron insufficient or iron-deficient with anaemia. The review also found three controlled studies providing evidence to suggest a role for zinc supplementation as a treatment for depressive symptoms, as both an adjunct to traditional antidepressant therapy for individuals with a diagnosis of major depressive disorder and as a therapy in its own right in pre-menopausal women with zinc deficiency. Overall, the current literature indicates a positive effect of improving zinc status on enhanced cognitive and emotional functioning. However, further study involving well-designed randomized controlled trials is needed to identify the impact of improving iron and zinc status on mood and cognition.
登录
查看更多内容
影响因子：
6.6
作者：
Siwek, Marcin;Dudek, Dominika;Nowak, Gabriel
通讯作者：
Nowak, Gabriel
影响因子：
7.1
作者：
Murray-Kolb, Laura E.;Beard, John L.
通讯作者：
Beard, John L.
影响因子：
168.9
作者：
Bruner, AB;Joffe, A;Brandt, J
通讯作者：
Brandt, J
影响因子：
4.2
作者：
KING, JC
通讯作者：
KING, JC
影响因子：
7.1
作者：
Sandstead, Harold H.;Prasad, Ananda S.;Zavaleta, Antonio N.
通讯作者：
Zavaleta, Antonio N.