Coloring ultrasensitive MRI with tunable metal-organic frameworks.
Coloring ultrasensitive MRI with tunable metal-organic frameworks.
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使用可调谐金属有机框架对超灵敏 MRI 进行着色
DOI：
10.1039/d0sc06969h
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发表时间：
2021-02-09
期刊：
影响因子：
8.4
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Yang Y;Zhang Y;Wang B;Guo Q;Yuan Y;Jiang W;Shi L;Yang M;Chen S;Lou X;Zhou X
作为最重要的成像方式之一，磁共振成像（MRI）仍然面临着相对较低的灵敏度，以监测低丰度分子。超极化129磁共振成像（MRI）是一种新发展起来的技术，它可以将信号灵敏度提高到常规MRI条件下的1万倍以上，这种技术被称为超灵敏MRI。然而，由于难以实现有利的“笼”来捕获信号源，即129个氘原子，因此在该领域中很少有方法可视化复杂的混合物。在这里，我们提出了金属有机框架（MOFs）作为可调的纳米多孔主机提供合适的腔氙。由于广泛分散的光谱信号，通过将每个化学位移分配给特定的颜色，可以很容易地观察到不同MOF中的129。结果表明，孔径大小决定了交换速率，几何结构和元素组成影响了氙的局部电荷。我们证实，一个复杂的混合物首先区分了特定的颜色在超灵敏的MRI。MOF的引入有助于克服超灵敏、多路复用MRI中的长期障碍。具有可调孔结构的金属有机框架能够为超极化的129 π原子托管提供不同的化学环境，这导致区分磁共振信号，并将超灵敏的磁共振成像（MRI）染色为不同的颜色。
As one of the most important imaging modalities, magnetic resonance imaging (MRI) still faces relatively low sensitivity to monitor low-abundance molecules. A newly developed technology, hyperpolarized 129Xe magnetic resonance imaging (MRI), can boost the signal sensitivity to over 10 000-fold compared with that under conventional MRI conditions, and this technique is referred to as ultrasensitive MRI. However, there are few methods to visualize complex mixtures in this field due to the difficulty in achieving favorable “cages” to capture the signal source, namely, 129Xe atoms. Here, we proposed metal–organic frameworks (MOFs) as tunable nanoporous hosts to provide suitable cavities for xenon. Due to the widely dispersed spectroscopic signals, 129Xe in different MOFs was easily visualized by assigning each chemical shift to a specific color. The results illustrated that the pore size determined the exchange rate, and the geometric structure and elemental composition influenced the local charge experienced by xenon. We confirmed that a complex mixture was first differentiated by specific colors in ultrasensitive MRI. The introduction of MOFs helps to overcome long-standing obstacles in ultrasensitive, multiplexed MRI. Metal organic frameworks with tunable pore structures are able to provide varied chemical environments for hyperpolarized 129Xe atom hosting, which results in distinguishing magnetic resonance signals, and stains ultra-sensitive magnetic resonance imaging (MRI) with diverse colors.
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