An overview of bacterial meningitis epidemics in Africa from 1928 to 2018 with a focus on epidemics "outside-the-belt".
An overview of bacterial meningitis epidemics in Africa from 1928 to 2018 with a focus on epidemics "outside-the-belt".
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DOI：
10.1186/s12879-021-06724-1
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发表时间：
2021-09-30
影响因子：
3.7
通讯作者：
Broutin H
中科院分区：
文献类型：
--
作者：
Mazamay S;Guégan JF;Diallo N;Bompangue D;Bokabo E;Muyembe JJ;Taty N;Vita TP;Broutin H
细菌性脑膜炎在世界各地都有发生，但非洲仍然是受影响最严重的大陆，特别是在从塞内加尔到埃塞俄比亚的“脑膜炎带”。造成细菌性脑膜炎的主要细菌有三种，即脑膜炎奈瑟菌、肺炎链球菌和b型流感嗜血杆菌。在脑膜炎奈瑟菌中，血清A群曾导致非洲高达80%至85%的脑膜炎球菌脑膜炎病例。自2000年以来，包括W、X和C在内的其他Nm血清群也引起了流行病。本综述旨在描述1928年至2018年非洲脑膜炎疾病病例和病原体的主要模式，特别关注通常尚未探索的“带外”地区的疾病状况。基于基本的时空方法和世界卫生组织90年来报告的疑似脑膜炎病例和死亡病例数据库，我们使用地理信息系统和时空统计来确定这一时期非洲脑膜炎流行的主要地区。细菌性脑膜炎今天扩展到脑膜炎带的历史范围之外。自2010年引进MenAfrivac疫苗以来，NmA病例大幅减少，而其他病原体物种和NmA变体，包括NmW、NmC和肺炎链球菌，却变得更加普遍，反映出当今非洲引起脑膜炎流行的细菌菌株更加多样化。今天，细菌性脑膜炎仍然是非洲的一个主要公共卫生问题。该疾病以前集中在具有撒哈拉以南和苏丹环境条件的脑膜炎带区域，现在已扩展到这些历史范围之外，到达非洲大陆中部更多的森林地区。随着全球环境的变化和针对独特血清群的大规模疫苗接种，细菌性脑膜炎的流行病学转变正在进行，这需要更好地考虑致病因子及其近端和远端决定因素的病原学性质。在线版本包含补充材料，可在10.1186/s12879-021-06724-1获得。
Bacterial meningitis occurs worldwide but Africa remains the most affected continent, especially in the "Meningitis belt" that extends from Senegal to Ethiopia. Three main bacteria are responsible for causing bacterial meningitis, i.e., N. meningitidis (Nm), S. pneumoniae and H. influenzae type b. Among Nm, serogroup A used to be responsible for up to 80 to 85% of meningococcal meningitis cases in Africa. Since 2000, other Nm serogroups including W, X and C have also been responsible for causing epidemics. This overview aims to describe the main patterns of meningitis disease cases and pathogens from 1928 to 2018 in Africa with a special focus on disease conditions “out-of-the-belt” area that is still usually unexplored. Based on basic spatio-temporal methods, and a 90-years database of reported suspected meningitis cases and death from the World Health Organization, we used both geographic information system and spatio-temporal statistics to identify the major localizations of meningitis epidemics over this period in Africa. Bacterial meningitis extends today outside its historical limits of the meningitis belt. Since the introduction of MenAfrivac vaccine in 2010, there has been a dramatic decrease in NmA cases while other pathogen species and Nm variants including NmW, NmC and Streptococcus pneumoniae have become more prevalent reflecting a greater diversity of bacterial strains causing meningitis epidemics in Africa today. Bacterial meningitis remains a major public health problem in Africa today. Formerly concentrated in the region of the meningitis belt with Sub-Saharan and Sudanian environmental conditions, the disease extends now outside these historical limits to reach more forested regions in the central parts of the continent. With global environmental changes and massive vaccination targeting a unique serogroup, an epidemiological transition of bacterial meningitis is ongoing, requiring both a better consideration of the etiological nature of the responsible agents and of their proximal and distal determinants. The online version contains supplementary material available at 10.1186/s12879-021-06724-1.
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影响因子：
13.6
作者：
Besancenot, JP;Boko, M;Oke, PC
通讯作者：
Oke, PC
影响因子：
4.8
作者：
LaForce, F. Marc;Djingarey, Mamoudou;Preziosi, Marie-Pierre
通讯作者：
Preziosi, Marie-Pierre
DOI：
10.1016/j.jaci.2016.04.062
发表时间：
2017-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Jusot JF;Neill DR;Waters EM;Bangert M;Collins M;Bricio Moreno L;Lawan KG;Moussa MM;Dearing E;Everett DB;Collard JM;Kadioglu A
通讯作者：
Kadioglu A
影响因子：
8.4
作者：
Ceyhan, Mehmet;Anis, Sameh;Vyse, Andrew
通讯作者：
Vyse, Andrew
影响因子：
5.5
作者：
Cuevas, Luis E.;Jeanne, Isabelle;Thomson, Madeleine C.
通讯作者：
Thomson, Madeleine C.