SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021.
SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021.
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DOI：
10.1186/s12916-021-02187-y
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发表时间：
2021-11-19
期刊：
影响因子：
9.3
通讯作者：
Jambo KC
中科院分区：
文献类型：
--
作者：
Mandolo J;Msefula J;Henrion MYR;Brown C;Moyo B;Samon A;Moyo-Gwete T;Makhado Z;Ayres F;Motlou T;Mzindle N;Kalata N;Muula AS;Kwatra G;Nsamala N;Likaka A;Mfune T;Moore PL;Mbaya B;French N;Heyderman RS;Swarthout T;Jambo KC
截至二零二一年八月，新型冠状病毒疫情在撒哈拉以南非洲的严重程度低于其他地区。在马拉维，随后出现了三波流行病。因此，我们的目的是描述在马拉维的SARS-CoV-2暴露的动态。我们使用横断面研究设计，测量了2020年1月至2021年7月在马拉维随机选择的输血供体血清中抗SARS-CoV-2抗体的血清阳性率。在一个子集中，我们还评估了对原始变体（D 614 G WT）和β变体的体外中和作用。从献血者数据库中共选择了5085份样本，其中4075份（80.1%）年龄为20-49岁。其中1 401人血清反应呈阳性。经调整化验特征及应用人口权重后，血清阳性率于二零二零年十月（18. 5%）及二零二一年五月（64. 9%）达到高峰，反映前两波疫情。与第一波疫情不同，第二波疫情中城市和农村地区的血清阳性率都很高，巴拉卡（农村，66.2%，2021年4月）、布兰太尔（城市，75.6%，2021年5月）、利隆圭（城市，78.0%，2021年5月）和姆祖祖（城市，74.6%，2021年4月）。布兰太尔和姆祖祖也显示出第三波大流行开始的迹象，血清阳性率在2021年7月再次回升（布兰太尔，81.7%;姆祖祖，71.0%）。与β变体（22% [2/9]）相比，更多的第一波血清显示出对原始变体（78% [7/9]）的体外中和活性，而与原始变体（63% [10/16]）相比，更多的第二波血清显示出对β变体（75% [12/16]）的中和活性。研究结果证实，马拉维在两波流行中广泛接触SARS-CoV-2，第一波和第二波之间的交叉保护可能很差。因此，在马拉维和整个地区制定COVID-19疫苗接种政策时，需要考虑SARS-CoV-2暴露的动态。未来的研究应使用足够的样本量来评估一组关注/感兴趣的SARS-CoV-2变体的中和活性，以估计群体免疫力。在线版本包含补充材料，可通过10.1186/s12916-021-02187-y获得。
By August 2021, the COVID-19 pandemic has been less severe in sub-Saharan Africa than elsewhere. In Malawi, there have been three subsequent epidemic waves. We therefore aimed to describe the dynamics of SARS-CoV-2 exposure in Malawi. We measured the seroprevalence of anti-SARS-CoV-2 antibodies amongst randomly selected blood transfusion donor sera in Malawi from January 2020 to July 2021 using a cross-sectional study design. In a subset, we also assessed in vitro neutralisation against the original variant (D614G WT) and the Beta variant. A total of 5085 samples were selected from the blood donor database, of which 4075 (80.1%) were aged 20–49 years. Of the total, 1401 were seropositive. After adjustment for assay characteristics and applying population weights, seropositivity reached peaks in October 2020 (18.5%) and May 2021 (64.9%) reflecting the first two epidemic waves. Unlike the first wave, both urban and rural areas had high seropositivity in the second wave, Balaka (rural, 66.2%, April 2021), Blantyre (urban, 75.6%, May 2021), Lilongwe (urban, 78.0%, May 2021), and Mzuzu (urban, 74.6%, April 2021). Blantyre and Mzuzu also show indications of the start of a third pandemic wave with seroprevalence picking up again in July 2021 (Blantyre, 81.7%; Mzuzu, 71.0%). More first wave sera showed in vitro neutralisation activity against the original variant (78% [7/9]) than the beta variant (22% [2/9]), while more second wave sera showed neutralisation activity against the beta variant (75% [12/16]) than the original variant (63% [10/16]). The findings confirm extensive SARS-CoV-2 exposure in Malawi over two epidemic waves with likely poor cross-protection to reinfection from the first on the second wave. The dynamics of SARS-CoV-2 exposure will therefore need to be taken into account in the formulation of the COVID-19 vaccination policy in Malawi and across the region. Future studies should use an adequate sample size for the assessment of neutralisation activity across a panel of SARS-CoV-2 variants of concern/interest to estimate community immunity. The online version contains supplementary material available at 10.1186/s12916-021-02187-y.
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DOI：
10.1016/j.xcrm.2021.100290
发表时间：
2021-06-15
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Anand SP;Prévost J;Nayrac M;Beaudoin-Bussières G;Benlarbi M;Gasser R;Brassard N;Laumaea A;Gong SY;Bourassa C;Brunet-Ratnasingham E;Medjahed H;Gendron-Lepage G;Goyette G;Gokool L;Morrisseau C;Bégin P;Martel-Laferrière V;Tremblay C;Richard J;Bazin R;Duerr R;Kaufmann DE;Finzi A
通讯作者：
Finzi A
影响因子：
3.3
作者：
Ho, Antonia;Mallewa, Jane;Heyderman, Robert S.
通讯作者：
Heyderman, Robert S.
DOI：
10.4269/ajtmh.20-1235
发表时间：
2021-01
期刊：
The American journal of tropical medicine and hygiene
影响因子：
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作者：
Olayanju O;Bamidele O;Edem F;Eseile B;Amoo A;Nwaokenye J;Udeh C;Oluwole G;Odok G;Awah N
通讯作者：
Awah N
影响因子：
7.7
作者：
Henrion MY
通讯作者：
Henrion MY
DOI：
10.1016/j.bpa.2020.11.009
发表时间：
2021-10
期刊：
Best practice & research. Clinical anaesthesiology
影响因子：
--
作者：
Kaye AD;Okeagu CN;Pham AD;Silva RA;Hurley JJ;Arron BL;Sarfraz N;Lee HN;Ghali GE;Gamble JW;Liu H;Urman RD;Cornett EM
通讯作者：
Cornett EM