Integration of a graphite/poly(methyl-methacrylate) composite electrode into a poly(methylmethacrylate) substrate for electrochemical detection in microchips.

Integration of a graphite/poly(methyl-methacrylate) composite electrode into a poly(methylmethacrylate) substrate for electrochemical detection in microchips.
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DOI:
10.1002/elps.201300055
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发表时间:
2013-07
期刊:
影响因子:
2.9
通讯作者:
Lunte, Susan
Lunte, Susan
中科院分区:
生物学3区
文献类型:
--
作者:
Regel, Anne;Lunte, Susan

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Traditional fabrication methods for polymer microchips, the bonding of two substrates together to form the microchip, can make the integration of carbon electrodes difficult. We have developed a simple and inexpensive method to integrate graphite/PMMA composite electrodes (GPCEs) into a PMMA substrate. These substrates can be bonded to other PMMA layers using a solvent-assisted thermal bonding method. The optimal composition of the GPCEs for electrochemical detection was determined using cyclic voltammetry with dopamine as a test analyte. Using the optimized GPCEs in an all-PMMA flow cell with flow injection analysis, it was possible to detect 50 nM dopamine under the best conditions. These electrodes were also evaluated for the detection of dopamine and catechol following separation by microchip electrophoresis (ME).
六氰基铁酸钴修饰多壁碳纳米管/石墨复合电极作为微流控芯片电化学传感器
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