Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla.
Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla.
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DOI：
10.1002/mrm.26592
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发表时间：
2017-11
影响因子：
3.3
通讯作者：
Hillenbrand CM
中科院分区：
文献类型：
--
作者：
Krafft AJ;Loeffler RB;Song R;Tipirneni-Sajja A;McCarville MB;Robson MD;Hankins JS;Hillenbrand CM
由于信号的快速衰减，使用多梯度回波(MGRE)成像的R2*-MRI定量肝脏铁含量(HIC)会向高HIC或更高的磁场方向折衷。我们的研究旨在提出一种用于R2*量化的优化的2D UTE序列来克服这些限制。二维UTE成像采用半脉冲激励和径向中心偏心采样。该序列包括国际象棋脉冲，以减少皮下脂肪和空间饱和(SSAT)带的条纹伪影，以抑制切片外信号。该序列使用交错多回声读出序列来实现对快速信号衰减的密集时间采样。在模体中进行1.5T和3T的评估，并在5名经活检证实为大量高HIC水平(>；25 mg Fe/g干重肝组织)的患者中证明了临床适用性。在模体中，SSAT脉冲被发现可以去除片外污染，并且R2*结果与参考mGRE R2*结果非常一致(1.5/3T的线性回归斜率：1.02/1.00)。大量铁负荷患者基于UTE的R2*定量在两种场强下均被证明是成功的，并且与活检HIC值一致。UTE序列提供了一种在1.5T和3T下测量大量铁超载患者R2*的方法。
Hepatic iron content (HIC) quantification via R2*-MRI using multi gradient echo (mGRE) imaging is compromised towards high HIC or at higher fields due to the rapid signal decay. Our study aims at presenting an optimized 2D UTE sequence for R2* quantification to overcome these limitations. 2D UTE imaging was realized via half pulse excitation and radial center-out sampling. The sequence includes CHESS pulses to reduce streaking artifacts from subcutaneous fat and spatial saturation (sSAT) bands to suppress out-of-slice signals. The sequence employs interleaved multi-echo readout trains to achieve dense temporal sampling of rapid signal decays. Evaluation at 1.5T and 3T was done in phantoms and clinical applicability demonstrated in five patients with biopsy-confirmed massively high HIC levels (>25 mg Fe/g dry weight liver tissue). In phantoms, the sSAT pulses were found to remove out-of-slice contamination, and R2* results were in excellent agreement to reference mGRE R2* results (slope of linear regression: 1.02/1.00 for 1.5/3T). UTE-based R2* quantification in patients with massive iron overload proved successful at both field strengths and was consistent with biopsy HIC values. The UTE sequence provides a means to measure R2* in patients with massive iron overload both, at 1.5T and 3T.
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影响因子：
5.7
作者：
Du J;Ma G;Li S;Carl M;Szeverenyi NM;VandenBerg S;Corey-Bloom J;Bydder GM
通讯作者：
Bydder GM
影响因子：
4.1
作者：
Biswas, Reni;Bae, Won;Diaz, Eric;Masuda, Koichi;Chung, Christine B.;Bydder, Graeme M.;Du, Jiang
通讯作者：
Du, Jiang
影响因子：
10.6
作者：
Harkins, Kevin D.;Does, Mark D.;Grissom, William A.
通讯作者：
Grissom, William A.
影响因子：
5.9
作者：
Chandarana, Hersh;Block, Kai T.;Milla, Sarah S.
通讯作者：
Milla, Sarah S.
影响因子：
2.9
作者：
Du, Jiang;Bydder, Graeme M.
通讯作者：
Bydder, Graeme M.