Cell identity regulators link development and stress responses in the Arabidopsis root.
Cell identity regulators link development and stress responses in the Arabidopsis root.
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DOI：
10.1016/j.devcel.2011.09.009
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发表时间：
2011-10-18
影响因子：
11.8
通讯作者：
Benfey, Philip N.
中科院分区：
文献类型：
--
作者：
Iyer-Pascuzzi, Anjali S.;Jackson, Terry;Cui, Hongchang;Petricka, Jalean J.;Busch, Wolfgang;Tsukagoshi, Hironaka;Benfey, Philip N.
植物的胁迫反应与发育过程密切相关，但这些途径之间的相互作用却知之甚少。我们使用高时空分辨率的全基因组分析来了解拟南芥根中发育和胁迫之间的联系。我们的荟萃分析发现几乎没有证据表明普遍的压力反应。然而，常见的应激反应似乎存在，其中许多表现出细胞类型特异性。常见的应激反应可能是由细胞身份调节因子介导的，因为这些基因的突变导致了对应激反应的改变。细胞身份调节因子的直接作用的证据来自关键调节因子SCARECROW的全基因组结合谱，其显示与应激反应基因的调节区域结合。应激共表达被用来鉴定参与特定发育过程的基因。这些结果揭示了细胞分辨率下应激与发育之间令人惊讶的联系，并显示了多个全基因组数据集阐明生物过程的能力。
Stress responses in plants are tightly coordinated with developmental processes, but the interaction of these pathways is poorly understood. We used genome-wide assays at high spatio-temporal resolution to understand the processes that link development and stress in the Arabidopsis root. Our meta-analysis finds little evidence for a universal stress response. However, common stress responses appear to exist with many showing cell-type specificity. Common stress responses may be mediated by cell identity regulators, as mutations in these genes resulted in altered responses to stress. Evidence for a direct role for cell identity regulators came from genome-wide binding profiling of the key regulator SCARECROW, which showed binding to regulatory regions of stress-responsive genes. Co-expression in response to stress was used to identify genes involved in specific developmental processes. These results reveal surprising linkages between stress and development at cellular resolution, and show the power of multiple genome-wide datasets to elucidate biological processes.
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影响因子：
11.8
作者：
Busch, Wolfgang;Miotk, Andrej;Lohmann, Jan U.
通讯作者：
Lohmann, Jan U.
影响因子：
56.9
作者：
Dinneny, Jose R.;Long, Terri A.;Benfey, Philip N.
通讯作者：
Benfey, Philip N.
影响因子：
10.5
作者：
Kubo, M;Udagawa, M;Demura, T
通讯作者：
Demura, T
影响因子：
7.4
作者：
Karas, Bogumil;Amyot, Lisa;Szczyglowski, Krzysztof
通讯作者：
Szczyglowski, Krzysztof
影响因子：
11.6
作者：
Brown, DM;Zeef, LAH;Turner, SR
通讯作者：
Turner, SR