The Hidden Link of Exosomes to Head and Neck Cancer.
The Hidden Link of Exosomes to Head and Neck Cancer.
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DOI：
10.3390/cancers13225802
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发表时间：
2021-11-19
期刊：
影响因子：
5.2
通讯作者：
Ferlito A
中科院分区：
文献类型：
--
作者：
Teng Y;Gao L;Loveless R;Rodrigo JP;Strojan P;Willems SM;Nathan CA;Mäkitie AA;Saba NF;Ferlito A
头颈部鳞状细胞癌（HNSCC）是一组具有挑战性的恶性肿瘤，需要多学科的管理方法，其中靶向治疗的进展仍然相对微薄。尽管存在这些挑战，但免疫方法的最新进展对晚期疾病患者的临床结局产生了积极影响。然而，系统治疗的新方法仍然是这种疾病的迫切需要。这篇综述强调了外泌体在维持HNSCC恶性细胞中的可能作用，以及基于目前证据的这些细胞成分未来治疗干预的前景。头颈部鳞状细胞癌（HNSCC）是一组侵袭性和异质性的癌症，其病理学在很大程度上仍未得到解决。尽管最近在HNSCC治疗策略方面取得了进展，但HNSCC患者的总体生存率仍然很差，并继续促使人们努力开发更有效的治疗方法。外泌体是由多种细胞分泌的细胞外囊泡的一种亚型，这些细胞已开始引起人们对其在癌症中的作用的极大兴趣。作为直径为30-150 nm的膜囊泡，外泌体介导各种分子如蛋白质、核酸和脂质在整个身体中的细胞间转运。在这样做的过程中，外泌体不仅可以将物质传递给癌细胞，而且还可以作为可以赋予其进展的信号。越来越多的证据表明外泌体与HNSCC的侵袭性之间存在直接相关性。然而，在这一领域还需要更多的研究来加深我们的理解。在这篇综述中，我们试图强调外泌体在HNSCC中的肿瘤支持作用和治疗潜力。我们首先介绍了外泌体的生物起源和组成特点，其次是他们参与HNSCC增殖和转移。然后，我们继续讨论HNSCC衍生的外泌体对肿瘤微环境的影响及其在肿瘤耐药性中的作用。最后，我们探讨了外泌体作为HNSCC生物标志物和治疗靶点以及HNSCC治疗药物载体的潜力。
Head and neck squamous cell carcinomas (HNSCC) are a challenging group of malignancies that require a multidisciplinary management approach and where advances in targeted therapeutics remain relatively meager. Despite these challenges, recent advances in immunotherapeutic approaches have positively affected the clinical outcome for patients with advanced disease. Novel approaches for systemic therapy continue, however, to be an urgent need for this disease. This review highlights the possible role of exosomes in sustaining malignant cells in HNSCC and the prospects of future therapeutic interventions in these cellular components based on current evidence. Head and neck squamous cell carcinoma (HNSCC) represents an aggressive and heterogenous group of cancers whose pathologies remain largely unresolved. Despite recent advances in HNSCC therapeutic strategies, the overall survival of HNSCC patients remains poor and continues to prompt efforts to develop more effective therapies. Exosomes are a subtype of extracellular vesicles secreted by a variety of cells that have begun to spark significant interest in their roles in cancer. As membranous vesicles, spanning from 30–150 nm in diameter, exosomes mediate the transport of various molecules, such as proteins, nucleic acids, and lipids, intercellularly throughout the body. In doing so, exosomes not only act to deliver materials to cancer cells but also as signals that can confer their progression. Accumulating evidence shows the direct correlation between exosomes and the aggressiveness of HNSCC. However, more research is warranted in this field to further our understanding. In this review, we attempt to highlight the tumor-supporting roles and therapeutic potential of exosomes in HNSCC. We introduce first the biogenesis and component features of exosomes, followed by their involvement in HNSCC proliferation and metastasis. We then move on to discuss HNSCC-derived exosomes’ influence on the tumor microenvironment and their function in tumor drug resistance. Finally, we explore the promising potential of exosomes as HNSCC biomarkers and therapeutic targets and drug carriers for HNSCC treatments.
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影响因子：
4.2
作者：
Chiba M;Kimura M;Asari S
通讯作者：
Asari S
DOI：
10.1038/mt.2008.1
发表时间：
2008-04
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Dai S;Wei D;Wu Z;Zhou X;Wei X;Huang H;Li G
通讯作者：
Li G
DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
外泌体与乳腺癌耐药性
影响因子：
9
作者：
Dong X;Bai X;Ni J;Zhang H;Duan W;Graham P;Li Y
通讯作者：
Li Y
影响因子：
3.8
作者：
Byun, J-S;Hong, S-H;Lee, H-J
通讯作者：
Lee, H-J