Pallidal stimulation in Parkinson disease differentially modulates local and network β activity.
Pallidal stimulation in Parkinson disease differentially modulates local and network β activity.
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DOI：
10.1088/1741-2552/aad0fb
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发表时间：
2018-10
影响因子：
4
通讯作者：
Pouratian N
中科院分区：
文献类型：
--
作者：
Malekmohammadi M;Shahriari Y;AuYong N;O'Keeffe A;Bordelon Y;Hu X;Pouratian N
基底神经节-丘脑皮质（BGTC）网络内的β超同步性已被认为是帕金森病（PD）病理生理学的标志。丘脑底核（Subthalamic nucleus，DBS）-DBS已被证明可以改变皮质-皮质下同步。目前尚不清楚这是否是一种跨靶点治疗刺激的普遍现象。我们的目的是评估是否DBS的苍白球内（GPi）的结果在皮质-皮质下去皮质化，尽管缺乏单突触连接GPi和感觉运动皮质。我们记录了9名接受DBS植入的PD患者在停药后来自GPi的局部场电位（LFP）和来自同侧感觉运动皮质的皮质电图（ECoG）信号。我们分析了局部振荡功率和功能连接性（相干性和去偏加权相位滞后指数（dWPLI）），有和没有刺激，而受试者休息与眼睛睁开。DBS显著抑制了GPi内的低β功率（−26.98 ±15.14%，p<0.05），而不调制感觉运动皮质β功率（低或高）。相反，刺激抑制苍白球皮质高β相干性（−38.89 ± 6.19%，p=0.02）和dWPLI（−61.40 ± 8.75%，p= 0.02）。皮质-皮质下功能连接的变化在空间上特定于运动皮质。我们强调了DBS在降低网络活动中的作用，特别是在高β波段。目前对GPi-DBS的研究表明，这些网络水平的影响不一定是依赖性的，可能与超直接通路无关。重要的是，这些结果明确区分了基底神经节内局部低β振荡和BGTC运动回路中高β振荡的潜在意义。
β hypersynchrony within the basal ganglia-thalamocortical (BGTC) network has been suggested as a hallmark of Parkinson disease (PD) pathophysiology. Subthalamic nucleus (STN)-DBS has been shown to alter cortical-subcortical synchronization. It is unclear whether this is a generalizable phenomenon of therapeutic stimulation across targets. We aimed to evaluate whether DBS of the globus pallidus internus (GPi) results in cortical-subcortical desynchronization, despite the lack of monosynaptic connections between GPi and sensorimotor cortex. We recorded local field potentials (LFP) from the GPi and electrocorticographic (ECoG) signals from the ipsilateral sensorimotor cortex, off medications in nine PD patients, undergoing DBS implantation. We analyzed both local oscillatory power and functional connectivity (coherence and debiased weighted phase lag index (dWPLI)) with and without stimulation while subjects were resting with eyes open. DBS significantly suppressed low β power within the GPi (−26.98 ±15.14%), p<0.05) without modulation of sensorimotor cortical β power (low or high). In contrast, stimulation suppressed pallidocortical high β coherence (−38.89 ±6.19 %, p=0.02) and dWPLI (−61.40 ±8.75%, p= 0.02). Changes in cortical-subcortical functional connectivity were spatially specific to the motor cortex. We highlight the role of DBS in desynchronizing network activity, particularly in the high β band. The current study of GPi-DBS suggests these network-level effects are not necessarily dependent and potentially may be independent of the hyperdirect pathway. Importantly, these results draw a sharp distinction between the potential significance of low β oscillations locally within the basal ganglia and high β oscillations across the BGTC motor circuit.
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DOI：
10.1007/s11548-015-1189-y
发表时间：
2015-06
影响因子：
3
作者：
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