Current methods in the molecular typing of Mycobacterium tuberculosis and other mycobacteria.
Current methods in the molecular typing of Mycobacterium tuberculosis and other mycobacteria.
复制标题
DOI：
10.1155/2014/645802
复制
发表时间：
2014
影响因子：
--
通讯作者：
Bielecki J
中科院分区：
文献类型：
--
作者：
Jagielski T;van Ingen J;Rastogi N;Dziadek J;Mazur PK;Bielecki J
在结核病（TB）和非结核分枝杆菌（NTM）疾病的流行病学中，与所有传染病一样，关键问题是确定感染源并揭示其在环境中的传播和传播途径。为了实现这一点，辨别和跟踪单个分枝杆菌菌株的能力至关重要。分子分型方法极大地提高了我们对分枝杆菌生物学的理解，并为对抗这些病原体引起的疾病提供了强有力的工具。各种分型方法的实用性取决于所研究的分枝杆菌物种以及研究问题。对于结核病，不同的方法在系统发育分析和人际传播研究中具有不同的作用。在NTM疾病中，大多数调查涉及寻找环境来源或系统发育关系。在这方面，环境类型也决定了哪种方法最合适。本文综述了目前M.结核病和一些NTM物种，最常与人类疾病相关。对于各种方法，技术的实用性，以及歧视的权力和成就进行了审查。
In the epidemiology of tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases, as in all infectious diseases, the key issue is to define the source of infection and to disclose its routes of transmission and dissemination in the environment. For this to be accomplished, the ability of discerning and tracking individual Mycobacterium strains is of critical importance. Molecular typing methods have greatly improved our understanding of the biology of mycobacteria and provide powerful tools to combat the diseases caused by these pathogens. The utility of various typing methods depends on the Mycobacterium species under investigation as well as on the research question. For tuberculosis, different methods have different roles in phylogenetic analyses and person-to-person transmission studies. In NTM diseases, most investigations involve the search for environmental sources or phylogenetic relationships. Here, too, the type of setting determines which methodology is most suitable. Within this review, we summarize currently available molecular methods for strain typing of M. tuberculosis and some NTM species, most commonly associated with human disease. For the various methods, technical practicalities as well as discriminatory power and accomplishments are reviewed.
登录
查看更多内容
影响因子：
9.4
作者：
Blackwood, KS;Wolfe, JN;Kabani, AM
通讯作者：
Kabani, AM
影响因子：
28.2
作者：
Augustynowicz-Kopec, Ewa;Jagielski, Tomasz;Zwolska, Zofia
通讯作者：
Zwolska, Zofia
影响因子：
9.4
作者：
Bauer, J;Andersen, ÅB;Miörner, H
通讯作者：
Miörner, H
结核分枝杆菌复杂的遗传多样性：挖掘第四个国际螺旋型数据库（SpoldB4），用于分类，种群遗传学和流行病学。
影响因子：
4.2
作者：
Brudey K;Driscoll JR;Rigouts L;Prodinger WM;Gori A;Al-Hajoj SA;Allix C;Aristimuño L;Arora J;Baumanis V;Binder L;Cafrune P;Cataldi A;Cheong S;Diel R;Ellermeier C;Evans JT;Fauville-Dufaux M;Ferdinand S;Garcia de Viedma D;Garzelli C;Gazzola L;Gomes HM;Guttierez MC;Hawkey PM;van Helden PD;Kadival GV;Kreiswirth BN;Kremer K;Kubin M;Kulkarni SP;Liens B;Lillebaek T;Ho ML;Martin C;Martin C;Mokrousov I;Narvskaïa O;Ngeow YF;Naumann L;Niemann S;Parwati I;Rahim Z;Rasolofo-Razanamparany V;Rasolonavalona T;Rossetti ML;Rüsch-Gerdes S;Sajduda A;Samper S;Shemyakin IG;Singh UB;Somoskovi A;Skuce RA;van Soolingen D;Streicher EM;Suffys PN;Tortoli E;Tracevska T;Vincent V;Victor TC;Warren RM;Yap SF;Zaman K;Portaels F;Rastogi N;Sola C
通讯作者：
Sola C
影响因子：
11.8
作者：
Baker L;Brown T;Maiden MC;Drobniewski F
通讯作者：
Drobniewski F