SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions.
SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions.
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DOI：
10.1093/nar/gkp970
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发表时间：
2010-01
影响因子：
14.9
通讯作者：
Preissner R
中科院分区：
文献类型：
--
作者：
Preissner S;Kroll K;Dunkel M;Senger C;Goldsobel G;Kuzman D;Guenther S;Winnenburg R;Schroeder M;Preissner R
关于细胞色素P450酶（CYP）的许多信息都散布在文献和互联网上。将CYP相关知识汇总到一个数据库中，可提高搜索效率。对57种CYP和药物的文本挖掘产生了大量的论文，这些论文被人工筛选，以了解代谢、SNP及其对药物降解的影响。信息被输入数据库，使用户不仅可以查找特定的药物和所有代谢药物，还可以检查药物鸡尾酒的耐受性，并找到替代组合，更有效地使用代谢途径。该数据库包含1170种药物，超过3800种相互作用，包括参考文献。列出了大约2000种SNP和突变，并根据其对表达和/或活性的影响进行排序。Supercyp（http：//bioinformatics.charite.de/supercyp）是一个集中于CYP和药物代谢的综合资源。CYP的同源建模结构可以以PDB格式下载，相关药物可作为MOL文件获得。在资源中，CYP可以彼此对齐，药物鸡尾酒可以“混合”，SNP，蛋白质点突变，可以查看它们的影响，并给出相应的PubMed ID。Superculture旨在成为科学家和卫生专业人员进一步研究的平台和起点。
Much of the information on the Cytochrome P450 enzymes (CYPs) is spread across literature and the internet. Aggregating knowledge about CYPs into one database makes the search more efficient. Text mining on 57 CYPs and drugs led to a mass of papers, which were screened manually for facts about metabolism, SNPs and their effects on drug degradation. Information was put into a database, which enables the user not only to look up a particular CYP and all metabolized drugs, but also to check tolerability of drug-cocktails and to find alternative combinations, to use metabolic pathways more efficiently. The SuperCYP database contains 1170 drugs with more than 3800 interactions including references. Approximately 2000 SNPs and mutations are listed and ordered according to their effect on expression and/or activity. SuperCYP (http://bioinformatics.charite.de/supercyp) is a comprehensive resource focused on CYPs and drug metabolism. Homology-modeled structures of the CYPs can be downloaded in PDB format and related drugs are available as MOL-files. Within the resource, CYPs can be aligned with each other, drug-cocktails can be ‘mixed’, SNPs, protein point mutations, and their effects can be viewed and corresponding PubMed IDs are given. SuperCYP is meant to be a platform and a starting point for scientists and health professionals for furthering their research.
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DOI：
10.1159/000113876
发表时间：
2008-01-01
期刊：
COMMUNITY GENETICS
影响因子：
--
作者：
Jaja, Cheedy;Burke, Wylie;Veenstra, David L.
通讯作者：
Veenstra, David L.
影响因子：
1.9
作者：
Lepesheva, Galina I.;Hargrove, Tatyana Y.;Kleshchenko, Yuliya;Nes, W. David;Villalta, Fernando;Waterman, Michael R.
通讯作者：
Waterman, Michael R.
影响因子：
2.9
作者：
Fernando, H;Halpert, JR;Davydov, DR
通讯作者：
Davydov, DR
影响因子：
5.8
作者：
Arnold, K;Bordoli, L;Schwede, T
通讯作者：
Schwede, T
影响因子：
5.8
作者：
Fischer, Markus;Knoll, Michael;Pleiss, Juergen
通讯作者：
Pleiss, Juergen