White matter disruption in moderate/severe pediatric traumatic brain injury: advanced tract-based analyses.
White matter disruption in moderate/severe pediatric traumatic brain injury: advanced tract-based analyses.
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DOI：
10.1016/j.nicl.2015.02.002
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发表时间：
2015
影响因子：
4.2
通讯作者：
Asarnow, Robert F.
中科院分区：
文献类型：
--
作者：
Dennis, Emily L.;Jin, Yan;Villalon-Reina, Julio E.;Zhan, Liang;Kernan, Claudia L.;Babikian, Talin;Mink, Richard B.;Babbitt, Christopher J.;Johnson, Jeffrey L.;Giza, Christopher C.;Thompson, Paul M.;Asarnow, Robert F.
创伤性脑损伤（TBI）是儿童死亡和残疾的主要原因，可导致广泛的损伤。脑成像方法，如DTI（扩散张量成像）是唯一敏感的白色物质（WM）的损害是常见的TBI。然而，使用纤维束成像进行更高级别的分析会因TBI的损伤和FA（分数各向异性）特征降低而变得复杂，这可能导致过早的纤维束末端。我们使用新开发的autoMATE（自动多图谱道提取）方法来识别WM完整性的差异。对63例8-19岁中、重度TBI患儿在伤后1 ~ 2个时间点进行横断面扫描：伤后1-5个月进行急性期评估，伤后13-19个月进行慢性期评估。在相同的时间段内进行了一系列认知功能测试。第一阶段共检测儿童56例，其中TBI组28例，健康对照组28例。在第二阶段，研究了34名儿童，17名TBI患者和17名对照（27名参与者完成了急性期和慢性期）。在急性期后，我们没有发现任何显著的组间差异。长期来看，我们发现广泛的组间差异，主要是平均和径向扩散率（MD和RD）。在慢性期，我们发现更高的MD和RD在广泛的WM。此外，我们发现这些WM完整性措施和认知缺陷之间的相关性。这表明WM中断的分布模式在儿童TBI后的第一年继续。我们在伤后2个时间点检查了小儿创伤性脑损伤患者。在急性期和慢性期后完成横断面分析。我们使用新的基于束的方法来揭示广泛的白色物质破坏。慢性白色物质破坏与认知功能障碍有关。
Traumatic brain injury (TBI) is the leading cause of death and disability in children and can lead to a wide range of impairments. Brain imaging methods such as DTI (diffusion tensor imaging) are uniquely sensitive to the white matter (WM) damage that is common in TBI. However, higher-level analyses using tractography are complicated by the damage and decreased FA (fractional anisotropy) characteristic of TBI, which can result in premature tract endings. We used the newly developed autoMATE (automated multi-atlas tract extraction) method to identify differences in WM integrity. 63 pediatric patients aged 8–19 years with moderate/severe TBI were examined with cross sectional scanning at one or two time points after injury: a post-acute assessment 1–5 months post-injury and a chronic assessment 13–19 months post-injury. A battery of cognitive function tests was performed in the same time periods. 56 children were examined in the first phase, 28 TBI patients and 28 healthy controls. In the second phase 34 children were studied, 17 TBI patients and 17 controls (27 participants completed both post-acute and chronic phases). We did not find any significant group differences in the post-acute phase. Chronically, we found extensive group differences, mainly for mean and radial diffusivity (MD and RD). In the chronic phase, we found higher MD and RD across a wide range of WM. Additionally, we found correlations between these WM integrity measures and cognitive deficits. This suggests a distributed pattern of WM disruption that continues over the first year following a TBI in children. We examined pediatric traumatic brain injury patients at 2 time points post injury. Cross sectional analyses were completed at the post-acute and chronic stages. We used novel tract-based methods to reveal widespread white matter disruption. White matter disruption chronically was related to cognitive deficits.
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DOI：
10.1017/s1355617710001189
发表时间：
2011-01
影响因子：
2.6
作者：
de la Plata, Carlos D. Marquez;Yang, Fanpei Gloria;Wang, Jun Yi;Krishnan, Kamini;Bakhadirov, Khamid;Paliotta, Christopher;Aslan, Sina;Devous, Michael D., Sr.;Moore, Carol;Harper, Caryn;McColl, Roderick;Cullum, C. Munro;Diaz-Arrastia, Ramon
通讯作者：
Diaz-Arrastia, Ramon
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC
影响因子：
4.2
作者：
Kochunov, P.;Williamson, D. E.;Lancaster, J.;Fox, P.;Cornell, J.;Blangero, J.;Glahn, D. C.
通讯作者：
Glahn, D. C.
影响因子：
5.7
作者：
Hua X;Leow AD;Parikshak N;Lee S;Chiang MC;Toga AW;Jack CR Jr;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative