Fractional anisotropy of water diffusion in cerebral white matter across the lifespan.
Fractional anisotropy of water diffusion in cerebral white matter across the lifespan.
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DOI：
10.1016/j.neurobiolaging.2010.01.014
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发表时间：
2012-01
影响因子：
4.2
通讯作者：
Glahn, D. C.
中科院分区：
文献类型：
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作者：
Kochunov, P.;Williamson, D. E.;Lancaster, J.;Fox, P.;Cornell, J.;Blangero, J.;Glahn, D. C.
确定大脑成熟高峰的时间对于我们理解健康老龄化中大脑成熟何时停止以及大脑退化何时开始至关重要。我们仔细绘制了一个大组（831名）11-90岁健康人受试者的11个主要脑白色物质束的水扩散各向异性分数（FA）的变化。FA是微结构白色物质完整性的神经影像学指标，对脑髓鞘水平的年龄相关变化敏感，使用扩散张量成像测量。脑白色物质FA值在32±6岁时达到高峰。除了一个主要的皮质白色物质束（皮质-脊髓）外，所有的FA测量值在23至39岁之间达到峰值。峰龄前的成熟率与峰龄后的下降率显著相关（r=0.74; p= 0.01）。胼胝体（CC）的区域分析表明，薄的髓鞘，密集的纤维，连接前额叶区，成熟后，并表现出较高的下降比更厚的髓鞘运动和感觉领域的身体和压部的CC。我们的研究结果可以概括为：相关的，大脑WM束，达到其峰值FA值后，在生活中也表现出越来越高的年龄相关性下降比早熟的运动和感觉束。这些发现对成熟和衰老的神经生物学的理论研究以及神经精神疾病的临床研究都具有多重和不同的意义。
Determining the time of peak of cerebral maturation is vital for our understanding of when cerebral maturation ceases and the cerebral degeneration in healthy aging begins. We carefully mapped changes in fractional anisotropy (FA) of water diffusion for eleven major cerebral white matter tracts in a large group (831) of healthy human subjects aged 11–90. FA is a neuroimaging index of micro-structural white matter integrity, sensitive to age-related changes in cerebral myelin levels, measured using diffusion tensor imaging. The average FA values of cerebral white matter (WM) reached peak at the age 32±6 years. FA measurements for all but one major cortical white matter tract (cortico-spinal) reached peaks between 23 and 39 years of age. The maturation rates, prior to age-of-peak were significantly correlated (r=0.74; p=.01) with the rates of decline, past age-of-peak. Regional analysis of corpus callosum (CC) showed that thinly-myelinated, densely packed fibers in the genu, that connect pre-frontal areas, maturated later and showed higher decline in aging than the more thickly myelinated motor and sensory areas in the body and splenium of CC. Our findings can be summarized as: associative, cerebral WM tracts that reach their peak FA values later in life also show progressively higher age-related decline than earlier maturing motor and sensory tracts. These findings carry multiple and diverse implications for both theoretical studies of the neurobiology of maturation and aging and for the clinical studies of neuropsychiatric disorders.
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影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
影响因子：
--
作者：
den Heijer, T;Geerlings, MI;Breteler, MMB
通讯作者：
Breteler, MMB
影响因子：
2.9
作者：
Hasan KM;Iftikhar A;Kamali A;Kramer LA;Ashtari M;Cirino PT;Papanicolaou AC;Fletcher JM;Ewing-Cobbs L
通讯作者：
Ewing-Cobbs L
影响因子：
4.2
作者：
Bartzokis, G;Sultzer, D;Cummings, JL
通讯作者：
Cummings, JL
DOI：
10.1523/jneurosci.4184-08.2009
发表时间：
2009-02-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chiang MC;Barysheva M;Shattuck DW;Lee AD;Madsen SK;Avedissian C;Klunder AD;Toga AW;McMahon KL;de Zubicaray GI;Wright MJ;Srivastava A;Balov N;Thompson PM
通讯作者：
Thompson PM