Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering.
Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering.
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DOI：
10.1007/s00784-012-0763-8
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发表时间：
2013-01
影响因子：
3.4
通讯作者：
Handschel, Joerg
中科院分区：
文献类型：
--
作者：
Langenbach, Fabian;Naujoks, Christian;Smeets, Ralf;Berr, Karin;Depprich, Rita;Kuebler, Norbert;Handschel, Joerg
本文的目的是综述牙本质过敏症（DHS），讨论疼痛的机制和病因。使用搜索引擎检索MESH术语、DH疼痛机制和病因（包括磨损、糜烂和牙周病）对文献进行综述。DHS提出的许多假设证明了我们在理解神经生理机制方面缺乏知识，最广泛接受的是流体动力学理论。牙本质小管从口腔环境到牙髓必须是开放的。牙本质暴露，通常在颈部边缘，是由于各种过程，包括牙龈退缩或釉质损失，诱发因素是牙周病和治疗，有限的牙槽骨，薄生物型，侵蚀和磨损。目前DHS的疼痛机制被认为是流体力学理论。DHS的发生和发展受牙齿和牙周组织的特征以及口腔环境和外部影响的影响。风险因素很多，往往协同作用，并始终受到个人易感性的影响。虽然DHS的疼痛机制尚未得到很好的理解，但临床医生需要注意病因和风险因素，以管理患者的疼痛和期望，并防止牙本质进一步暴露，随后出现敏感性。
The paper’s aim is to review dentin hypersensitivity (DHS), discussing pain mechanisms and aetiology. Literature was reviewed using search engines with MESH terms, DH pain mechanisms and aetiology (including abrasion, erosion and periodontal disease). The many hypotheses proposed for DHS attest to our lack of knowledge in understanding neurophysiologic mechanisms, the most widely accepted being the hydrodynamic theory. Dentin tubules must be patent from the oral environment to the pulp. Dentin exposure, usually at the cervical margin, is due to a variety of processes involving gingival recession or loss of enamel, predisposing factors being periodontal disease and treatment, limited alveolar bone, thin biotype, erosion and abrasion. The current pain mechanism of DHS is thought to be the hydrodynamic theory. The initiation and progression of DHS are influenced by characteristics of the teeth and periodontium as well as the oral environment and external influences. Risk factors are numerous often acting synergistically and always influenced by individual susceptibility. Whilst the pain mechanism of DHS is not well understood, clinicians need to be mindful of the aetiology and risk factors in order to manage patients’ pain and expectations and prevent further dentin exposure with subsequent sensitivity.
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