High-Resolution Focused Ultrasound Neuromodulation Induces Limb-Specific Motor Responses in Mice in Vivo.
High-Resolution Focused Ultrasound Neuromodulation Induces Limb-Specific Motor Responses in Mice in Vivo.
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DOI：
10.1016/j.ultrasmedbio.2020.12.013
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发表时间：
2021-04
影响因子：
2.9
通讯作者：
Konofagou EE
中科院分区：
文献类型：
--
作者：
Aurup C;Kamimura HAS;Konofagou EE
超声波可以调节中枢神经系统的活动，包括诱导啮齿动物的运动反应。最近对超声诱导的运动运动的研究大多描述了双侧肢体的反应，但定量评估未能显示侧边化或不同肢体之间反应特征的差异，也未能显示特定的大脑目标如何指示不同的肢体反应。本研究使用高分辨率聚焦超声（FUS）在体内诱导麻醉小鼠的运动反应，并使用四肢肌电图（EMG）评估配对运动反应的潜伏期、持续时间和功率（n = 1768）。结果表明，FUS在肌电特征上产生了靶特异性的差异，相隔仅1 mm的脑靶可以对单个肢体的反应产生不同的调节。利用这些差异可以为量化潜在神经体积对FUS的易感性提供工具，了解目标神经解剖学的功能，并有助于这种非侵入性神经调节技术的机制研究。
Ultrasound can modulate activity in the central nervous system, including the induction of motor responses in rodents. Recent studies investigating ultrasound-induced motor movements have described mostly bilateral limb responses, but quantitative evaluations have failed to show lateralization or differences in response characteristics between separate limbs or how specific brain targets dictate distinct limb responses. This study uses high-resolution focused ultrasound (FUS) to elicit motor responses in anesthetized mice in vivo and four-limb electromyography (EMG) to evaluate the latency, duration, and power of paired motor responses (n = 1768). The results show that FUS generates target-specific differences in EMG characteristics and that brain targets separated by as little as 1 mm can modulate the responses in individual limbs differentially. Exploiting these differences may provide a tool for quantifying the susceptibility of underlying neural volumes to FUS, understanding the functioning of the targeted neuroanatomy, and aiding in mechanistic studies of this non-invasive neuromodulation technique.
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