Long Non-Coding RNAs as Endogenous Target Mimics and Exploration of Their Role in Low Nutrient Stress Tolerance in Plants.

Long Non-Coding RNAs as Endogenous Target Mimics and Exploration of Their Role in Low Nutrient Stress Tolerance in Plants.
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长期非编码RNA作为内源性靶模拟物,并探索其在植物中养分低的胁迫耐受性中的作用。

DOI:
10.3390/genes9090459
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发表时间:
2018-09-14
期刊:
影响因子:
3.5
通讯作者:
Pandey R
Pandey R
中科院分区:
生物学3区
文献类型:
--
作者:
Borah P;Das A;Milner MJ;Ali A;Bentley AR;Pandey R

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植物中的长链非编码RNA(lncRNA)研究最近从动物系统的研究中获得了动力。下一代测序的可用性使得能够在几种植物物种中全基因组鉴定lncRNA。一些lncRNA是microRNA表达的抑制剂,并且具有称为靶标模拟的功能,其中隔离的转录物称为内源性靶标模拟物(eTM)。迄今为止鉴定的lncRNA显示了不同的基因调控机制,其中大多数仍然知之甚少。在这篇综述中,我们讨论了公认的lncRNA的作用,可能作为eTM的营养响应microRNA(miRNA)在植物中。如果功能得到验证,这些推定的lncRNA将提高目前的理解lncRNA在植物营养平衡中的作用。
Long non-coding RNA (lncRNA) research in plants has recently gained momentum taking cues from studies in animals systems. The availability of next-generation sequencing has enabled genome-wide identification of lncRNA in several plant species. Some lncRNAs are inhibitors of microRNA expression and have a function known as target mimicry with the sequestered transcript known as an endogenous target mimic (eTM). The lncRNAs identified to date show diverse mechanisms of gene regulation, most of which remain poorly understood. In this review, we discuss the role of identified putative lncRNAs that may act as eTMs for nutrient-responsive microRNAs (miRNAs) in plants. If functionally validated, these putative lncRNAs would enhance current understanding of the role of lncRNAs in nutrient homeostasis in plants.
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