Hippocampal functional connectivity development during the first two years indexes 4-year working memory performance.
Hippocampal functional connectivity development during the first two years indexes 4-year working memory performance.
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DOI：
10.1016/j.cortex.2021.02.005
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Gao W
中科院分区：
文献类型：
--
作者：
Liu J;Chen Y;Stephens R;Cornea E;Goldman B;Gilmore JH;Gao W
海马体是参与包括学习和记忆在内的高级认知过程的关键边缘系统区域。虽然海马的典型和非典型功能连接模式在成年人中已经得到了很好的研究，但婴儿期海马连接的发展轨迹以及它与以后工作记忆表现的关系仍有待阐明。在这里，我们使用静息状态功能磁共振成像（rsfMRI）在自然睡眠中检查海马功能连接的纵向发展，使用一个大的队列（N=202）的婴儿在3周（新生儿），1年，2岁。接下来，我们使用多变量模型来研究海马连接的横截面和纵向生长与4年工作记忆结果之间的关系。结果显示，新生儿海马与附近的边缘和皮质下区域的局部功能连接性强，与关键默认模式网络（DMN）区域的连接性显著成熟和增加，导致第一年年底海马功能连接性的成人样拓扑结构。这一模式在2岁时得到稳定和进一步巩固。重要的是，第一年海马连接的横截面和纵向测量预测了4岁时工作记忆的后续行为测量。总之，我们的研究结果提供了深入了解海马功能电路的发展基础工作记忆在这个早期的关键时期。
The hippocampus is a key limbic region involved in higher-order cognitive processes including learning and memory. Although both typical and atypical functional connectivity patterns of the hippocampus have been well-studied in adults, the developmental trajectory of hippocampal connectivity during infancy and how it relates to later working memory performance remains to be elucidated. Here we used resting state fMRI (rsfMRI) during natural sleep to examine the longitudinal development of hippocampal functional connectivity using a large cohort (N=202) of infants at 3 weeks (neonate), 1 year, and 2 years of age. Next, we used multivariate modeling to investigate the relationship between both cross-sectional and longitudinal growth in hippocampal connectivity and 4-year working memory outcome. Results showed robust local functional connectivity of the hippocampus in neonates with nearby limbic and subcortical regions, with dramatic maturation and increasing connectivity with key default mode network (DMN) regions resulting in adult-like topology of the hippocampal functional connectivity by the end of the first year. This pattern was stabilized and further consolidated by 2 years of age. Importantly, cross-sectional and longitudinal measures of hippocampal connectivity in the first year predicted subsequent behavioral measures of working memory at 4 years of age. Taken together, our findings provide insight into the development of hippocampal functional circuits underlying working memory during this early critical period.
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