Effect of wearing a face mask on fMRI BOLD contrast.
Effect of wearing a face mask on fMRI BOLD contrast.
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DOI：
10.1016/j.neuroimage.2021.117752
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发表时间：
2021-04-01
期刊：
影响因子：
5.7
通讯作者：
Glover GH
中科院分区：
文献类型：
--
作者：
Law CSW;Lan PS;Glover GH
冠状病毒SARS-CoV-2的国际传播促使许多MRI扫描设施要求扫描对象在扫描期间佩戴面部覆盖物（“口罩”），以预防病毒传播。因为佩戴面罩将呼出的空气与受试者吸入的气流混合，吸入的二氧化碳[CO2]浓度升高，导致轻度高碳酸血症。已证明吸入气体混合物的变化会改变R2* 加权血氧依赖（BOLD）对比度。在这项研究中，我们探讨了潜在的面部掩蔽，以改变BOLD对比度的感觉运动任务，旨在激活视觉，听觉和感觉运动皮层在8名受试者。我们利用鼻插管向佩戴外科口罩的受试者供应空气，以90秒的开关块来置换呼出的CO2，同时受试者执行感觉运动任务。虽然只有一小部分（2.5%）的感觉运动任务激活与鼻空气调制，30.0%的变化，灰质BOLD信号基线被发现由于空气调制。在移除面罩的情况下重复扫描会在来自鼻腔空气供应的BOLD基线信号中产生小的受试者特异性偏差，这可能是由于气流或插管诱导的缺氧的认知影响。二氧化碳监测显示，戴口罩导致ETCO 2平均增加7.4%。总之，这些结果表明，戴口罩梯度回波功能磁共振成像过程中可以改变BOLD基线信号，但影响最小的任务激活。
International spread of the coronavirus SARS-CoV-2 has prompted many MRI scanning facilities to require scan subjects to wear a facial covering (“mask”) during scanning as a precaution against transmission of the virus. Because wearing a mask mixes expired air with the subject's inspired air stream, the concentration of inspired carbon dioxide [CO2] is elevated, resulting in mild hypercapnia. Changes in the inspired gas mixture have been demonstrated to alter R2*-weighted Blood Oxygen Dependent (BOLD) contrast. In this study, we investigate a potential for face masking to alter BOLD contrast during a sensory-motor task designed to activate visual, auditory, and sensorimotor cortices in 8 subjects. We utilize a nasal cannula to supply air to the subject wearing a surgical mask in on-off blocks of 90s to displace expired CO2, while the subject performs the sensory-motor task. While only a small fraction (2.5%) of the sensory-motor task activation is related to nasal air modulation, a 30.0% change in gray matter BOLD signal baseline is found due to air modulation. Repeating the scan with mask removed produces a small subject-specific bias in BOLD baseline signal from nasal air supply, which may be due to cognitive influence of airflow or cannula-induced hypoxia. Measurements with capnography demonstrate wearing a mask induces an average increase in ETCO2 of 7.4%. Altogether, these results demonstrate that wearing a face mask during gradient-echo fMRI can alter BOLD baseline signal but minimally affects task activation.
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DOI：
10.1097/00004647-199701000-00009
发表时间：
1997-01-01
影响因子：
6.3
作者：
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影响因子：
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TERPOGOS.MM
DOI：
10.1073/pnas.95.4.1834
发表时间：
1998-02-17
影响因子：
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