Fonofos exposure and cancer incidence in the agricultural health study.
Fonofos exposure and cancer incidence in the agricultural health study.
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DOI：
10.1289/ehp.9301
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发表时间：
2006-12
影响因子：
10.4
通讯作者：
Alavanja MC
中科院分区：
文献类型：
--
作者：
Mahajan R;Blair A;Lynch CF;Schroeder P;Hoppin JA;Sandler DP;Alavanja MC
农业健康研究（AHS）是一项前瞻性队列研究，研究对象是1993-1997年入组的爱荷华州和北卡罗来纳州的持牌农药施用者，并随访至2002年的癌症发病率。该队列中先前的一项研究将接触有机磷甲拌磷与有前列腺癌家族史的受试者发生前列腺癌联系起来。这一发现沿着有机磷农药与癌症之间更广泛联系的发现，导致了这项对参加AHS的45，372名农药施用者的fonofos和任何癌症风险的研究。农药接触和其他数据是使用自填问卷收集的。Poisson回归用于计算率比（RR）和95%置信区间（CI），同时控制潜在混杂因素。相对于未暴露者，在生命周期（RR = 2.24; 95%CI，0.94-5.34，ptrend = 0.07）和强度加权的暴露天数（RR = 2.67; 95%CI，1.06-6.70，ptrend = 0.04）的最高类别中，白血病风险升高，这是一种考虑了改变农药暴露因素的措施。虽然前列腺癌的风险与使用氟氯磷总体上无关，但在有前列腺癌家族史的施用者中，我们观察到终生使用氟氯磷的剂量反应趋势（p趋势= 0.02，RR最高三分位数与未暴露者= 1.77，95%CI，1.03-3.05; RR相互作用= 1.28，95%CI，1.07-1.54）。强度加权结果相似。未观察到与其他检查的癌症部位相关。进一步的研究是必要的，以确认有关白血病的发现，并确定遗传易感性是否改变农药暴露的前列腺癌风险。
The Agricultural Health Study (AHS) is a prospective cohort study of licensed pesticide applicators from Iowa and North Carolina enrolled 1993–1997 and followed for incident cancer through 2002. A previous investigation in this cohort linked exposure to the organophosphate fonofos with incident prostate cancer in subjects with family history of prostate cancer. This finding along with findings of associations between organophosphate pesticides and cancer more broadly led to this study of fonofos and risk of any cancers among 45,372 pesticide applicators enrolled in the AHS. Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. Relative to the unexposed, leukemia risk was elevated in the highest category of lifetime (RR = 2.24; 95% CI, 0.94–5.34, ptrend = 0.07) and intensity-weighted exposure-days (RR = 2.67; 95% CI, 1.06–6.70, ptrend = 0.04), a measure that takes into account factors that modify pesticide exposure. Although prostate cancer risk was unrelated to fonofos use overall, among applicators with a family history of prostate cancer, we observed a significant dose–response trend for lifetime exposure-days (ptrend = 0.02, RR highest tertile vs. unexposed = 1.77, 95% CI, 1.03–3.05; RRinteraction = 1.28, 95% CI, 1.07–1.54). Intensity-weighted results were similar. No associations were observed with other examined cancer sites. Further study is warranted to confirm findings with respect to leukemia and determine whether genetic susceptibility modifies prostate cancer risk from pesticide exposure.
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影响因子：
5.4
作者：
Acquavella, JF;Alexander, BH;Gustin, C
通讯作者：
Gustin, C
DOI：
10.1016/0165-1218(82)90161-6
发表时间：
1982-01-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
GENTILE, JM;GENTILE, GJ;PLEWA, MJ
通讯作者：
PLEWA, MJ
影响因子：
3.9
作者：
Usmani, KA;Rose, RL;Hodgson, E
通讯作者：
Hodgson, E
影响因子：
5
作者：
Alavanja, MCR;Dosemeci, M;Blair, A
通讯作者：
Blair, A
影响因子：
5
作者：
Alavanja, MCR;Samanic, C;Blair, A
通讯作者：
Blair, A