Reduced sleep and impaired sleep initiation in adult male rats exposed to alcohol during early postnatal period.
Reduced sleep and impaired sleep initiation in adult male rats exposed to alcohol during early postnatal period.
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DOI：
10.1016/j.bbr.2012.06.002
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发表时间：
2012-09-01
影响因子：
2.7
通讯作者：
Kubin, Leszek
中科院分区：
文献类型：
--
作者：
Volgin, Denys V.;Kubin, Leszek
产前酒精暴露(AE)与认知和神经行为异常有关，例如运动活动增加和焦虑升高，这些可能持续一生。持续的睡眠中断可能是这些问题的根源。使用大鼠模型，我们研究了在一个关键的早期发育期，癫痫后睡眠-觉醒行为的长期变化。雄性大鼠在出生后第4~9天(相当于妊娠晚期)灌胃酒精2.6g/kg，每日2次，或假插管(S组)。在PD52-80上，他们被用来记录拴系脑电和颈项肌电，并习惯于记录程序。然后记录一次长达24小时的睡眠-觉醒行为。对10个S时期的受试者在亮灯(休息)6h和熄灯(活动)6h期间进行觉醒、慢波睡眠和快速眼动睡眠评分。活动期，与S大鼠(N=6只/组)相比，AE组RMS百分率显著降低(4.7±0.9比8.2±0.9；p<；0.02)，SWS百分率也有降低趋势(p=0.07)。在休息期，两组大鼠的睡眠和觉醒时间没有差异，但AE大鼠出现短暂性睡眠障碍和快速睡眠障碍的潜伏期都较长(p分别为0.02和0.003)。我们的数据表明，在出生前癫痫的大鼠模型中，睡眠-觉醒行为受损一直持续到成年。睡眠障碍可能会加剧人类产前AE患者的认知和行为障碍。
Prenatal alcohol exposure (AE) is associated with cognitive and neurobehavioral abnormalities, such as increased motor activity and elevated anxiety, that may last a lifetime. Persistent sleep disruption may underlie these problems. Using a rat model, we investigated long-term alterations of sleep-wake behavior following AE during a critical early developmental period. Male rats received 2.6 g/kg of alcohol intragastrically twice daily on postnatal days (PD) 4-9, a developmental period equivalent to the third trimester of human pregnancy (AE group), or were sham-intubated (S group). On PD52-80, they were instrumented for tethered electroencephalogram and nuchal electromyogram recording and habituated to the recording procedures. Sleep-wake behavior was then recorded during one 24 h-long session. Wake, slow-wave sleep (SWS) and rapid eye movement sleep (REMS) were scored in 10 s epochs during 6 h of the lights-on (rest) and 6 h of the lights-off (active) periods. During the active period, REMS percentage was significantly lower (4.7±0.9 (SE) vs. 8.2±0.9; p<0.02) and the percentage of SWS tended to be lower (p=0.07) in AE than S rats (N=6/group). During the rest period, sleep and wake amounts did not differ between the groups, but AE rats had longer latency to both SWS and REMS onset (p=0.02 and 0.003, respectively). Our data demonstrate that, in a rat model of prenatal AE, impaired sleep-wake behavior persists into the adulthood. Disordered sleep may exacerbate cognitive and behavioral disorders seen in human victims of prenatal AE.
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影响因子：
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DOI：
10.1097/00000374-199810000-00032
发表时间：
1998-10-01
影响因子：
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作者：
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通讯作者：
Nyamweya, N