Acute-type acquired hemophilia A after COVID-19 mRNA vaccine administration: A new disease entity?
Acute-type acquired hemophilia A after COVID-19 mRNA vaccine administration: A new disease entity?
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急性型在19.MRNA疫苗给药后获得了血友病A：一种新疾病实体？
DOI：
10.1016/j.jaut.2022.102915
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发表时间：
2022-12
影响因子：
12.8
通讯作者：
Sonoki, Takashi
中科院分区：
文献类型：
--
作者：
Hosoi, Hiroki;Tane, Misato;Kosako, Hideki;Ibe, Masaki;Takeyama, Masahiro;Murata, Shogo;Mushino, Toshiki;Sonoki, Takashi
获得性血友病A(AHA)是一种罕见的自身免疫性出血性疾病。已有报道称，在接种新冠肺炎基因疫苗后，会发生各种自身免疫性疾病，包括急性血友病。然而，这些AHA病例的特征仍不清楚。我们报告了一例年轻患者在注射了新冠肺炎基因疫苗后出现的AHA，但病情迅速好转。患者的凝血因子(FVIII)抑制物效价自发下降到不到诊断时的一半。在最初的免疫抑制治疗一周后，FVIII抑制剂消失了。我们的病例提示，年轻患者接种新冠肺炎疫苗后出现的AHA可能会自发消退，在这种情况下，FVIII抑制剂的水平可能比特发性AHA下降得更快。与免疫性血小板减少性紫癜(ITP)不同的是，目前还没有发现急性AHA。这一案例表明，正如急性ITP在儿童中/在接种疫苗后发生一样，在接受MRNA新冠肺炎疫苗的年轻患者中可能会出现急性AHA。
Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder. Various autoimmune diseases, including AHA, have been reported to occur after the administration of mRNA COVID-19 vaccines. However, the characteristics of these AHA cases remain unclear. We report a case in which AHA arose in a young patient after the administration of an mRNA COVID-19 vaccine, but improved rapidly. The patient's factor VIII (FVIII) inhibitor titer spontaneously decreased to less than half of that seen at diagnosis. One week after the initial immunosuppressive therapy, the FVIII inhibitor had disappeared. Our case suggests that AHA that arises in young patients after COVID-19 vaccination may resolve spontaneously, and the levels of FVIII inhibitors may decrease more rapidly in such cases than in idiopathic AHA. Unlike for immune thrombocytopenic purpura (ITP), no acute type of AHA has been recognized. This case suggests that just as there is an acute type of ITP that develops in children/after vaccination, there may be an acute type of AHA that arises in young patients that receive mRNA COVID-19 vaccines.
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影响因子：
12.8
作者：
Tabata S;Hosoi H;Murata S;Takeda S;Mushino T;Sonoki T
通讯作者：
Sonoki T
影响因子：
10.4
作者：
Radwi, Mansoor;Farsi, Sara
通讯作者：
Farsi, Sara
影响因子：
1.3
作者：
Murali, Aarya;Wong, Philip;Mangos, Hilda M.
通讯作者：
Mangos, Hilda M.
DOI：
10.1111/j.1471-0528.2012.03469.x
发表时间：
2012-11-01
影响因子：
5.8
作者：
Tengborn, L.;Baudo, F.;Collins, P.
通讯作者：
Collins, P.
影响因子：
12.8
作者：
Bostan H;Ucan B;Kizilgul M;Calapkulu M;Hepsen S;Gul U;Ozturk Unsal I;Cakal E
通讯作者：
Cakal E