Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup.
Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup.
复制标题
钠/钾比值变化与血压变化相关：健康体检中钠/钾比值降低的群体方法的可能性。
DOI：
10.1038/s41440-020-00536-7
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Hozawa A
中科院分区：
文献类型：
--
作者：
Kogure M;Nakaya N;Hirata T;Tsuchiya N;Nakamura T;Narita A;Suto Y;Honma Y;Sasaki H;Miyagawa K;Ushida Y;Ueda H;Hozawa A
最近，据报道钠（Na）/钾（K）比值与血压（BP）相关。本文介绍了一种尿钠钾比值自动监测装置。在这里，我们评估了使用Na/K设备测量的尿Na/K比率变化是否与健康检查设置中的BP变化相关。我们以2017年至2018年期间在宫城托姆市参加健康检查的12，890名参与者为对象。托姆市自2017年起在健康检查期间引入尿Na/K比值测量。根据尿Na/K比值和血压水平，对每一年的基线特征进行比较。我们采用多元回归分析评估尿钠/钾比值变化与血压变化之间的关系，并对年龄、性别、体重指数（BMI）变化和饮酒量进行了校正。2018年平均尿Na/K比值明显低于2017年（5.4 ± 3.0至4.9 ± 2.2，P < 0.01）。2018年参与者的收缩压（130.9 ± 17.4 mmHg）低于2017年（132.1 ± 17.9 mmHg）。收缩压和舒张压的变化与尿Na/K比值的变化呈正相关。总之，尿钠/钾比值的变化与高血压和收缩压和舒张压的变化的关联可以通过酒精摄入量、BMI和尿钠/钾比值的变化来解释。因此，在社区环境中测量尿Na/K比值是对抗高血压的潜在人群方法。
Recently, the sodium (Na)/potassium (K) ratio was reported to be associated with blood pressure (BP). A Na/K ratio self-monitoring device using spot urine was established recently. Here, we assessed whether the urinary Na/K ratio change measured using the Na/K device was associated with BP change in a health checkup setting. We targeted 12,890 participants who attended the health checkup in Tome City, Miyagi between 2017 and 2018. Tome City introduced urinary Na/K ratio measurements during health checkups since 2017. For each year, we compared the baseline characteristics according to the urinary Na/K ratio and BP level. We assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, and change in body mass index (BMI) and alcohol intake. The average urinary Na/K ratio was significantly lower in 2018 than in 2017 (5.4 ± 3.0 to 4.9 ± 2.2, P < 0.01). The systolic BP of the participants in 2018 (130.9 ± 17.4 mmHg) was lower than that in 2017 (132.1 ± 17.9 mmHg). Moreover, the change in systolic BP and diastolic BP was positively associated with the change in urinary Na/K ratio. In conclusion, the association of the change in urinary Na/K ratio with hypertension and changes in systolic and diastolic BP can be explained by a change in alcohol intake, BMI, and urinary Na/K ratio. Therefore, measuring the urinary Na/K ratio in community settings is a potential population approach for counteracting hypertension.
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影响因子：
5.4
作者：
Kawano, Yuhei;Tsuchihashi, Takuya;Ueshima, Hirotsugu
通讯作者：
Ueshima, Hirotsugu
影响因子：
12.3
作者：
Hozawa, Atsushi;Kuriyama, Shinichi;Tsuji, Ichiro
通讯作者：
Tsuji, Ichiro
影响因子：
5.4
作者：
Iwahori, Toshiyuki;Miura, Katsuyuki;Stamler, Jeremiah
通讯作者：
Stamler, Jeremiah
DOI：
10.1038/s41440-019-0335-2
发表时间：
2020-01
期刊：
Hypertension research : official journal of the Japanese Society of Hypertension
影响因子：
--
作者：
Kogure M;Hirata T;Nakaya N;Tsuchiya N;Nakamura T;Narita A;Miyagawa K;Koshimizu H;Obara T;Metoki H;Uruno A;Kikuya M;Sugawara J;Kuriyama S;Tsuji I;Kure S;Hozawa A
通讯作者：
Hozawa A
影响因子：
158.5
作者：
Mente, Andrew;O'Donnell, Martin J.;Yusuf, Salim
通讯作者：
Yusuf, Salim