Endocytic signaling in leaves and roots: same rules different players.

Endocytic signaling in leaves and roots: same rules different players.
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DOI:
10.3389/fpls.2012.00219
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发表时间:
2012
影响因子:
5.6
通讯作者:
Yang Z
Yang Z
中科院分区:
生物学2区
文献类型:
--
作者:
Craddock C;Yang Z

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为了摄取细胞所需的蛋白质和其他成分,细胞将质膜 (PM) 的一部分内化,质膜内陷,在细胞质内形成封闭的囊泡,这一过程称为内吞作用。主要的植物内吞机制是由网格蛋白介导的,网格蛋白是在 PM 内侧生成包被囊泡所必需的蛋白质。这些囊泡从膜上发芽,产生囊泡,其内容物源自细胞外部,并且它们可以选择性地浓缩或排除化合物。因此,该过程对于植物生长、发育、信号传导、极性和养分输送至关重要。 Rho 家族小 GTP 酶是保守的分子开关,在许多信号转导事件中发挥作用。植物仅拥有一个 Rho 样 GTP 酶 (ROP) 家族。众所周知,ROP 通过调节内吞作用来控制细胞极性。为了应对此类过程所需的高水平调控,植物进化出了特定的调控因子,包括包含 Rop 交互 CRIB 基序的蛋白 (RIC) 效应子。最近的研究结果表明,ROP 动力学和细胞骨架(包括肌动蛋白微丝和微管)是交织在一起的。在这篇综述中,我们总结了目前对植物内吞作用的理解,特别是信号通路。
To take up proteins and other components required by the cell, cells internalize a portion of the plasma membrane (PM), which invaginates to form a closed vesicle within the cytoplasm in a process known as endocytosis. The major plant endocytic mechanism is mediated by clathrin, a protein that is necessary to generate a coated vesicle on the inner side of the PM. These vesicles bud away from the membrane generating a vesicle whose contents originated from outside of the cell and they can selectively concentrate or exclude compounds. The process is therefore of key importance to plant growth, development, signaling, polarity, and nutrient delivery. Rho family small GTPases are conserved molecular switches that function in many signaling events. Plants possess only a single Rho-like GTPase (ROP) family. ROPs are known to be involved in the control of cell polarity by regulating endocytosis. To contend with the high levels of regulation required for such processes, plants have evolved specific regulators, including the Rop-interactive CRIB motif-containing protein (RIC) effectors. Recent findings have demonstrated that ROP dynamics and the cytoskeleton (including actin microfilaments and microtubules) are interwoven. In this review, we summarize the current understanding of endocytosis in plants, with particular regard to the signaling pathways.
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