Adolescent adrenocortical activity and adiposity: differences by sex and exposure to early maternal depression.
Adolescent adrenocortical activity and adiposity: differences by sex and exposure to early maternal depression.
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DOI：
10.1016/j.psyneuen.2014.04.025
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发表时间：
2014-09
影响因子：
3.7
通讯作者：
Essex, Marilyn J.
中科院分区：
文献类型：
--
作者：
Ruttle, Paula L.;Klein, Marjorie H.;Slattery, Marcia J.;Kalin, Ned H.;Armstrong, Jeffrey M.;Essex, Marilyn J.
关键词：
先前的研究已经将基础皮质醇水平或压力诱导的皮质醇反应与肥胖联系起来;然而，这些不同的皮质醇措施是否产生联合或独立的影响仍有待确定。此外，尚不清楚它们如何与个体和环境特征相互作用来预测肥胖。本研究的目的是解决是否上午皮质醇水平和皮质醇反应的心理社会压力独立和/或交互影响身体质量指数（BMI）在218名青少年（117名女性）参与纵向社区研究，以及是否协会是由性别和暴露于早期产妇抑郁症的调节。母亲抑郁症状的报告，在婴儿期和学龄前获得。唾液皮质醇测量包括纵向早晨皮质醇测量，包括11岁、13岁、15岁和18岁的采样点，以及通过特里尔社会压力测试（TSST）在18岁时评估的压力诱导的皮质醇反应的测量。较低的早晨皮质醇和较高的TSST皮质醇反应独立预测较高的年龄18 BMI。早晨皮质醇也与性别和暴露于早期母亲抑郁症预测BMI相互作用。具体来说，女孩暴露于较低水平的早期母亲抑郁症显示出强烈的负面早晨皮质醇BMI协会，女孩暴露于较高水平的母亲抑郁症表现出较弱的负相关。在男孩中，那些暴露于较低水平的母亲抑郁症的人没有显示出相关性，而那些暴露于较高水平的母亲抑郁症的人显示出早晨皮质醇-BMI的负相关性。结果表明，独立的，加性效应的早晨和反应性皮质醇的BMI的预测，并建议暴露于早期的母亲抑郁症可能会产生性二态性的影响规范皮质醇BMI协会。
Prior research has linked either basal cortisol levels or stress-induced cortisol responses to adiposity; however, it remains to be determined whether these distinct cortisol measures exert joint or independent effects. Further, it is unclear how they interact with individual and environmental characteristics to predict adiposity. The present study aims to address whether morning cortisol levels and cortisol responses to a psychosocial stressor independently and/or interactively influence body mass index (BMI) in 218 adolescents (117 female) participating in a longitudinal community study, and whether associations are moderated by sex and exposure to early maternal depression. Reports of maternal depressive symptoms were obtained in infancy and preschool. Salivary cortisol measures included a longitudinal morning cortisol measure comprising sampling points across ages 11, 13, 15, and 18 and measures of stress-induced cortisol responses assessed via the Trier Social Stress Test (TSST) at age 18. Lower morning cortisol and higher TSST cortisol reactivity independently predicted higher age 18 BMI. Morning cortisol also interacted with sex and exposure to early maternal depression to predict BMI. Specifically, girls exposed to lower levels of early maternal depression displayed a strong negative morning cortisol-BMI association, and girls exposed to higher levels of maternal depression demonstrated a weaker negative association. Among boys, those exposed to lower levels of maternal depression displayed no association, while those exposed to higher levels of maternal depression displayed a negative morning cortisol-BMI association. Results point to the independent, additive effects of morning and reactive cortisol in the prediction of BMI and suggest that exposure to early maternal depression may exert sexually dimorphic effects on normative cortisol-BMI associations.
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影响因子：
2.6
作者：
Brydon, Lena
通讯作者：
Brydon, Lena
影响因子：
6.9
作者：
Champaneri, Shivam;Xu, Xiaoqiang;Carnethon, Mercedes R.;Bertoni, Alain G.;Seeman, Teresa;DeSantis, Amy S.;Roux, Ana Diez;Shrager, Sandi;Golden, Sherita Hill
通讯作者：
Golden, Sherita Hill
DOI：
10.1097/00004583-200205000-00017
发表时间：
2002-05-01
影响因子：
13.3
作者：
Essex, MJ;Boyce, WT;Kupfer, DJ
通讯作者：
Kupfer, DJ
影响因子：
3.7
作者：
Benson, S.;Arck, P. C.;Elsenbruch, S.
通讯作者：
Elsenbruch, S.
影响因子：
8.2
作者：
Dougherty, Lea R.;Klein, Daniel N.;Laptook, Rebecca S.
通讯作者：
Laptook, Rebecca S.