Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson's Disease.
Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson's Disease.
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漆黄素调节肠道微生物群并对帕金森病小鼠模型发挥神经保护作用
DOI：
10.3389/fnins.2020.549037
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发表时间：
2020
影响因子：
4.3
通讯作者：
Wu YC
中科院分区：
文献类型：
--
作者：
Chen TJ;Feng Y;Liu T;Wu TT;Chen YJ;Li X;Li Q;Wu YC
先前的研究报道了非瑟酮的抗氧化、抗炎和抗癌作用。然而，非瑟酮对帕金森病（PD）的治疗效果尚不清楚。在这项研究中，我们证明非瑟酮可以显着减轻 1-甲基-4-苯基-1,2,3,6-四氢吡啶 (MPTP) 诱导的小鼠多巴胺能神经变性。为了证实肠道微生物群与 PD 之间的相关性，对每组小鼠新鲜粪便中的细菌 DNA 进行了 16S rRNA（V3 和 V4 区域）测序。结果表明，非瑟酮改变了 MPTP 诱导的 PD 小鼠模型肠道微生物群的数量、多样性和分布。 α和β多样性分析表明，与MPTP组肠道菌群相比，非瑟酮干预的MPTP组肠道菌群表现出显着较高的毛螺旋菌科丰度和显着较低的uncultured_bacteria_g_Escherichia-Shigella和uncultured_bacteria_g_Bacillus丰度。这些发现表明，非瑟酮通过改变肠道微生物群的组成和多样性，对神经退行性疾病发挥神经保护作用。因此，非瑟酮可能是一种潜在的帕金森病新疗法。
Previous studies have reported the anti-oxidant, anti-inflammatory, and anti-cancer effects of fisetin. However, the therapeutic efficacy of fisetin in Parkinson’s disease (PD) is unclear. In this study, we demonstrated that fisetin could markedly alleviate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in mice. To confirm the reported correlation between gut microbiota and PD, the bacterial DNA in the fresh feces of mice from each group was subjected to 16S rRNA (V3 and V4 regions) sequencing. The results revealed that fisetin changed the number, diversity, and distribution of gut microbiota in MPTP-induced mice model of PD. The alpha and beta diversity analyses showed that the fisetin intervented MPTP group gut microbiota exhibited a significantly higher abundance of Lachnospiraceae and a significantly lower abundance of uncultured_bacterium_g_Escherichia-Shigella and uncultured_bacterium_g_Bacillus than the MPTP group gut microbiota. These findings indicated that fisetin exerts a neuroprotective effect on neurodegeneration by altering the composition and diversity of gut microbiota. Thus, fisetin could be a potential novel therapeutic for PD.
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影响因子：
4.6
作者：
Harach T;Marungruang N;Duthilleul N;Cheatham V;Mc Coy KD;Frisoni G;Neher JJ;Fåk F;Jucker M;Lasser T;Bolmont T
通讯作者：
Bolmont T
影响因子：
15.1
作者：
Liao, Jian-Fu;Cheng, Yun-Fang;Tsai, Ying-Chieh
通讯作者：
Tsai, Ying-Chieh
影响因子：
4.1
作者：
Lin, Aiqun;Zheng, Wenxia;Xie, Huifang
通讯作者：
Xie, Huifang
影响因子：
5.1
作者：
Ahmad, Ashfaq;Ali, Tahir;Kim, Myeong Ok
通讯作者：
Kim, Myeong Ok
影响因子：
168.9
作者：
Kalia, Lorraine V.;Lang, Anthony E.
通讯作者：
Lang, Anthony E.