Activation of satellite glial cells in the trigeminal ganglion contributes to masseter mechanical allodynia induced by restraint stress in rats
Activation of satellite glial cells in the trigeminal ganglion contributes to masseter mechanical allodynia induced by restraint stress in rats
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三叉神经节卫星胶质细胞的激活导致大鼠束缚应激引起的咬肌机械异常性疼痛
DOI：
10.1016/j.neulet.2015.06.048
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发表时间：
2015-08
影响因子：
2.5
通讯作者：
Chen, Yong-Jin
中科院分区：
文献类型：
--
作者：
Zhao, Yin-Hua;Li, Qiang;Zhang, Min;Chen, Yong-Jin
人们普遍认为心理压力会导致慢性口腔面部疼痛的发生。然而，这一过程背后的神经机制仍不清楚。本研究旨在探讨三叉神经节(TG)内卫星神经胶质细胞(SGCs)在应激性大鼠咬肌痛觉异常增加中的作用。使用慢性束缚应激模型，我们发现暴露于14天的应激而不是3天的应激(每天6小时)会导致大鼠体重增加、行为变化和明显的咬肌痛。TG组SGCs显著激活，P物质(SP)表达显著增加。慢性束缚应激后，SGCs的IL-1β和IL-1R I的表达显著增加，而TG内注射SGCs的L-β和IL-1R I则显著抑制这些蛋白的过度表达。此外，三叉神经节内注射LAA或白介素1受体拮抗剂(IL-1ra)可明显减轻束缚应激所致的机械性咬肌痛痛和SP的过度表达。这些结果提示，三叉神经节内SGC的激活可能在束缚应激引起的咬肌痛过敏症中起一定作用。IL-1β的过度释放和IL-1-RI的过度表达与应激性咬肌痛密切相关。
It is commonly accepted that psychological stress contributes to the development of chronic orofacial pain. However, the neural mechanism underlying this process has remained unclear. The present study was performed to determine the involvement of satellite glia cells (SGCs) in the trigeminal ganglion (TG) in stress-induced increases in masseter muscle allodynia in rats. Using a chronic restraint stress model, we found that exposure to a 14-day stress but not a 3-day stress (6 h/day) caused decreased body weight gain, behavioral changes and marked masseter allodynia in rats. SGCs were dramatically activated, and substance P (SP) expression was significantly increased in the TG. A further analysis was undertaken to investigate the contribution of SGCs; the expression of interleukin-1β (IL-1β) in SGCs and interleukin-1 receptor I (IL-1RI) in neurons was significantly increased after chronic restraint stress, whereas injection ofL-α-aminoadipate (a SGC inhibitor, LAA) into the TG dramatically inhibited the overexpression of these proteins. In addition, LAA or interleukin-1 receptor antagonist (IL-1ra) administration into the TG could significantly attenuate the mechanical masseter allodynia and overexpression of SP in the TG induced by restraint stress. These results suggest that SGC activation in the TG may play a role in masseter allodynia induced by restraint stress. The over-release of IL-1β and excessive IL1-RI expressions have close relationship with the stress induced masseter allodynia.
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心理压力会引起大鼠暂时的咀嚼肌机械敏感性。
影响因子：
--
作者：
Huang F;Zhang M;Chen YJ;Li Q;Wu AZ
通讯作者：
Wu AZ
DOI：
10.1111/j.1460-9568.2012.08100.x
发表时间：
2012-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Okamoto K;Tashiro A;Chang Z;Thompson R;Bereiter DA
通讯作者：
Bereiter DA
影响因子：
--
作者：
P. Rammelsberg;L. Leresche;S. Dworkin;L. Mancl
通讯作者：
P. Rammelsberg;L. Leresche;S. Dworkin;L. Mancl
影响因子：
2.5
作者：
Duenes SL;Thompson R;Chang Z;Okamoto K;Bereiter DA
通讯作者：
Bereiter DA
影响因子：
7.4
作者：
Takeda, M;Tanimoto, T;Matsumoto, S
通讯作者：
Matsumoto, S