Polypharmacy in older adults with cancer undergoing radiotherapy: A review.
Polypharmacy in older adults with cancer undergoing radiotherapy: A review.
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接受放射治疗的老年癌症患者的多药治疗：综述。
DOI：
10.1016/j.jgo.2022.02.007
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发表时间：
2022-07
影响因子：
3
通讯作者：
Nightingale, Ginah
中科院分区：
文献类型：
--
作者：
Novak, Jennifer;Goldberg, Annette;Dharmarajan, Kavita;Amini, Arya;Maggiore, Ronald J.;Presley, Carolyn J.;Nightingale, Ginah
多药联用的特点是同时使用多种药物，包括处方药、非处方药和营养补充剂。众所周知，多药联用会增加药物不良反应、药物相互作用和用药差错的风险，并对生活质量产生负面影响。多种药物的流行率因人口而异，但据报道，在患有癌症的老年人中超过90%。在接受放射治疗的老年癌症患者中，由于所产生的急性或慢性副作用，需要通过额外的药物治疗，多药联用可能会加剧。为管理与辐射有关的副作用而开的药物增加了不良药物事件的风险，与放射治疗的次要副作用有关的营养状况的变化也是如此。治疗的副作用可能导致癌症治疗中断或治疗延迟，最终可能导致更糟糕的肿瘤学结果。很少有研究在老年人接受放射治疗的背景下考察多药联用。我们试图回顾与癌症老年患者进行多药联用相关的文献，并特别讨论对那些接受放射治疗的患者的影响。本文介绍了过去十年发表的研究的叙述性回顾，这些研究提供了关于接受癌症放射治疗的老年人的多药联用的详细信息。这项综述阐明了避免综合药房不良药物事件的良好做法，但还需要更多的研究来制定标准指南。
Polypharmacy is characterized by the simultaneous use of multiple medications, including prescription drugs, over-the-counter drugs, and nutritional supplements. Polypharmacy is known to increase the risk of adverse drugs reactions, drug-drug interactions, and medication errors, and to negatively impact quality of life. The prevalence of polypharmacy varies by population, but has been reported to exceed 90% among older adults with cancer. Polypharmacy may be exacerbated among older adults with cancer receiving radiation therapy due to the resulting acute or chronic side effects that need to be managed with additional medications. The medications prescribed to manage radiation-related side effects increase the risk of adverse drug events, as do changes in nutritional status related to the secondary side effects of radiation treatment. Side effects from treatment may result in the need for breaks in cancer therapy or treatment delays, which ultimately can lead to worse oncologic outcomes. Few studies have examined polypharmacy in the context of older adults undergoing radiation therapy. We sought to review the literature pertaining to polypharmacy among older adults with cancer and discuss implications specifically for those individuals undergoing radiation therapy. This paper presents a narrative review of studies published in the past decade that provided detailed information on polypharmacy in older adults undergoing radiation therapy for cancer. The review elucidated good practices to avoid adverse drug events from polypharmacy, but more studies are warranted to develop standard guidelines.
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影响因子：
6.4
作者：
Bairati, Isabelle;Meyer, Francois;Tetu, Bernard
通讯作者：
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作者：
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通讯作者：
FEUSSNER, JR
影响因子：
10.3
作者：
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通讯作者：
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